Figure 1. Overview of transmission of BSE-H isolates in tg110 mice. Five different isolates were intracerebrally inoculated into groups of 6–12 mice per isolate. Survival times at different serial passages are indicated as mean ± SD days postinoculation. Molecular profiles exhibited in the brains of inoculated mice are indicated as H-type, C-type, or C-like PrPres, and proportion of mice showing each profile. Previously reported data on BSE-C transmission in these mice (36) are included here only for comparison. BSE, bovine spongiform encephalitis; BSE-H, unglycosylated PrPres that is higher than BSE-C; H-type, high-type Western blot profile of PrPres; C-type, classical-type Western blot profile of PrPres; C-like, classical BSE–like; PrPres, protease-resistant prion protein; BSE-C, classical BSE.