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Volume 17, Number 9—September 2011

Research

Classical Bovine Spongiform Encephalopathy by Transmission of H-Type Prion in Homologous Prion Protein Context

Juan-María TorresComments to Author , Olivier Andréoletti, Caroline Lacroux, Irene Prieto, Patricia Lorenzo, Magdalena Larska, Thierry Baron, and Juan-Carlos Espinosa
Author affiliations: Author affiliations: Centro de Investigación en Sanidad Animal, Madrid, Spain (J.-M. Torres, I. Prieto, P. Lorenzo, M. Larska, J.-C. Espinosa); Ecole Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti, C. Lacroux); Agence Francaise de Sécurité Sanitaire des Aliments, Lyon, France (T. Baron)

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Figure 1

Overview of transmission of BSE-H isolates in tg110 mice. Five different isolates were intracerebrally inoculated into groups of 6–12 mice per isolate. Survival times at different serial passages are indicated as mean ± SD days postinoculation. Molecular profiles exhibited in the brains of inoculated mice are indicated as H-type, C-type, or C-like PrPres, and proportion of mice showing each profile. Previously reported data on BSE-C transmission in these mice (36) are included here only for comp

Figure 1. Overview of transmission of BSE-H isolates in tg110 mice. Five different isolates were intracerebrally inoculated into groups of 6–12 mice per isolate. Survival times at different serial passages are indicated as mean ± SD days postinoculation. Molecular profiles exhibited in the brains of inoculated mice are indicated as H-type, C-type, or C-like PrPres, and proportion of mice showing each profile. Previously reported data on BSE-C transmission in these mice (36) are included here only for comparison. BSE, bovine spongiform encephalitis; BSE-H, unglycosylated PrPres that is higher than BSE-C; H-type, high-type Western blot profile of PrPres; C-type, classical-type Western blot profile of PrPres; C-like, classical BSE–like; PrPres, protease-resistant prion protein; BSE-C, classical BSE.

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