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Volume 17, Number 9—September 2011

Research

Classical Bovine Spongiform Encephalopathy by Transmission of H-Type Prion in Homologous Prion Protein Context

Juan-María TorresComments to Author , Olivier Andréoletti, Caroline Lacroux, Irene Prieto, Patricia Lorenzo, Magdalena Larska, Thierry Baron, and Juan-Carlos Espinosa
Author affiliations: Author affiliations: Centro de Investigación en Sanidad Animal, Madrid, Spain (J.-M. Torres, I. Prieto, P. Lorenzo, M. Larska, J.-C. Espinosa); Ecole Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti, C. Lacroux); Agence Francaise de Sécurité Sanitaire des Aliments, Lyon, France (T. Baron)

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Figure 6

Vacuolar lesion profiles in brains from Tg110 mice inoculated with BSE-H (isolate 02-2695, first passage) showing either H-type PrPres phenotype (black triangles, n = 6 animals) or C-like PrPres phenotype (blue squares, n = 3 animals). Lesion profile in brains from Tg110 inoculated with BSE-C (first passage) is also included for comparison (red circles, n = 6 animals). Lesion scoring was undertaken for 9 areas of gray matter (G) and white matter (W) in mouse brains: dorsal medulla (G1), cerebell

Figure 6. Vacuolar lesion profiles in brains from Tg110 mice inoculated with BSE-H (isolate 02-2695, first passage) showing either H-type PrPres phenotype (black triangles, n = 6 animals) or C-like PrPres phenotype (blue squares, n = 3 animals). Lesion profile in brains from Tg110 inoculated with BSE-C (first passage) is also included for comparison (red circles, n = 6 animals). Lesion scoring was undertaken for 9 areas of gray matter (G) and white matter (W) in mouse brains: dorsal medulla (G1), cerebellar cortex (G2), superior colliculus (G3), hypothalamus (G4) medial thalamus (G5), hippocampus (G6), septum (G7), medial cerebral cortex at the level of the thalamus (G8) and at the level of the septum (G9), cerebellum (W1), mesencephalic tegmentum (W2), and pyramidal tract (W3). Error bars indicate SE. BSE, bovine spongiform encephalopathy; BSE-H, unglycosylated PrPres that is higher than BSE-C; PrPres, protease-resistant prion protein; H-type, high-type Western blot profile of PrPres; C-type, classical-type Western blot profile of PrPres; C-like, classical BSE–like; BSE-C, classical BSE.

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