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Volume 17, Number 9—September 2011

Letter

Pandemic (H1N1) 2009 in Neonates, Japan

Suggested citation for this article

To the Editor: In 2009 in Japan, a medical response to pandemic (H1N1) 2009 infection in neonates was proposed by the Japan Pediatric Society (JPS) (1). Few such cases have been reported (27). Because the effects of pandemic (H1N1) 2009 in neonates are unknown, the JPS Committee of Neonatal Medicine conducted a nationwide survey during 2009. Surveys were mailed to neonatal care units in 522 facilities certified by JPS as teaching hospitals, which included almost all tertiary neonatal intensive care units in Japan. The survey asked whether during April 2009–March 2010 any neonates had been born to mothers with pandemic (H1N1) 2009 onset from 7 days before delivery until obstetric discharge and whether pandemic (H1N1) 2009 developed in any neonates <28 days of age before hospital discharge. The study was approved by the Bioethics Committee and Board of Directors of JPS.

Of the 522 facilities, 327 (62.6%) responded. During the period in question, 52,774 neonates had been hospitalized for any cause except routine care. Pandemic (H1N1) 2009 infection of the mother was reported by 47 (16.1%) facilities. From the 37 of these facilities, detailed information was available for ≈42 mothers with pandemic (H1N1) 2009 infection who gave birth to 43 neonates (29 full-term and 14 preterm births). Of these 42 mothers, a diagnosis of influenza A was made by rapid influenza diagnostic kit for 33 (78.6%) and for pandemic (H1N1) 2009 by reverse transcription PCR (RT-PCR) for 5 (11.9%). Only 1 case of pandemic (H1N1) 2009 in a mother was reported in May 2009, when influenza subtype H3 was dominant in Japan. This infection was confirmed by RT-PCR, and the mother was included in the study.

During the study period, except April and May 2009, almost all influenza A infections were caused by pandemic (H1N1) 2009 virus. Delivery on the day after symptom onset was most frequent (14 [32.6%] births), followed by delivery on the same day as symptom onset (8 [18.6%] births). A similar trend was observed for preterm births. Of the 42 mothers, 40 (95.2%) received antiviral medications. Mixed feeding of breast and formula milk was most common, and 8 neonates were breast-fed only.

Among the 43 neonates, pandemic (H1N1) 2009 infection developed in only 1 (male, gestational age 37 weeks, birthweight 2,665 g). His mother had high fever, and pandemic (H1N1) 2009 was diagnosed by RT-PCR; she received oseltamivir and delivered her son 2 days after illness onset. The neonate became lethargic at 4 days of age, and pandemic (H1N1) 2009 infection was confirmed by a rapid-antigen detection kit. The neonate received oseltamivir and recovered the next day. He received oseltamivir for 5 days and was discharged at 12 days of age with no subsequent medical problems. Because onset occurred 4 days after birth, the possibility of horizontal infection from the mother cannot be excluded. Except for this 1 neonate, prophylactic antiviral drugs were not given to the other 42 neonates, none of whom became infected.

With respect to nosocomial pandemic (H1N1) 2009 infection in hospital wards caring for neonates, no cases of onset within 28 days after birth were reported. However, pandemic (H1N1) 2009 infection before discharge but after 28 days of age was reported for 6 neonates. These diagnoses were made by rapid diagnostic kit, specific RT-PCR, or both. Of these 6 neonates, 1 was born at 29 weeks of gestation and had a low birthweight (1,026 g); symptom onset at 32 days of age; and complications of respiratory distress, pneumothorax, and systemic inflammatory response syndrome. Oseltamivir was given to 5 of these 6 neonates, none had adverse effects and all 6 recovered.

Pandemic (H1N1) 2009 infection may have caused preterm labor. According to our findings, the virus does not seem to be transmitted during breast-feeding, and antiviral drugs, if given to the mothers, may not always be needed by neonates. However, because of the limitations of this observational study, these findings need further support. Dulyachai et al. confirmed vertical transmission of pandemic (H1N1) 2009 virus at 31 weeks of gestation (5). Jajoo and Gupta reported a 32-week-old preterm patient with pandemic (H1N1) 2009 who died of pneumonia and multiorgan failure (6). Maternal pandemic (H1N1) 2009 infection associated with preterm labor may adversely affect the fetus or neonate (2,3,5,6).

Our results show that pandemic (H1N1) 2009 virus infection in mothers seldom occurred in their neonates, i.e., vertical transmission was rare. This finding is consistent with the fact that few such cases have been reported (8,9). On the basis of the results of this survey, JPS published Guideline for Management of Influenza (including Pandemic [H1N1] 2009) in Neonates during the Early Postnatal Period in 2010–2011 Season (10).

Naoto TakahashiComments to Author , Hiroyuki Kitajima, Satoshi Kusuda, Ichiro Morioka, and Kazuo Itabashi
Author affiliations: Author affiliations: Jichi Medical University School of Medicine, Shimotsuke, Japan (N. Takahashi); Osaka Prefectural Medical Center for Perinatal Medicine and Child Health, Osaka, Japan (H. Kitajima); Tokyo Women’s Medical University, Tokyo, Japan (S. Kusuda); Kobe University Graduate School of Medicine, Kobe, Japan (I. Morioka); Showa University School of Medicine, Tokyo (K. Itabashi)

Acknowledgment

We extend our deep appreciation to the neonatologists from the JPS training facilities for their survey responses.

References

  1. Japan Pediatric Society. Guidelines on medical response for neonates with novel influenza (pandemic [H1N1] 2009) in the early neonatal period [in Japanese]. The Journal of Japan Pediatric Society. 2009;113:14924.
  2. Creanga AA, Johnson TF, Graitcer SB, Hartman LK, Al-Samarrai T, Schwarz AG, Severity of 2009 pandemic influenza A (H1N1) virus infection in pregnant women. Obstet Gynecol. 2010;115:71726. DOIPubMed
  3. Centers for Disease Control and Prevention. 2009 Pandemic influenza A (H1N1) in pregnant women requiring intensive care—New York City, 2009. MMWR Morb Mortal Wkly Rep. 2010;59:3216.PubMed
  4. Miroballi Y, Baird JS, Zackai S, Cannon J-M, Messina M, Ravindranath T, Novel influenza A (H1N1) in a pediatric health care facility in New York City during the first wave of the 2009 pandemic. Arch Pediatr Adolesc Med. 2010;164:2430. DOIPubMed
  5. Dulyachai W, Makkoch J, Rianthavorn P, Changpinyo M, Prayangprecha S, Payungporn S, Perinatal pandemic (H1N1) 2009 infection, Thailand. Emerg Infect Dis. 2010;16:3434.PubMed
  6. Jajoo M, Gupta R. H1N1 influenza in a preterm neonate. Indian J Pediatr. 2010;77:10456. DOIPubMed
  7. Sert A, Yazar A, Odabas D, Bilgin H. An unusual cause of fever in a neonate: influenza A (H1N1) virus pneumonia. Pediatr Pulmonol. 2010;45:7346. DOIPubMed
  8. Libster R, Burna J, Coviello S, Hijano DR, Dunaiewsky M, Reynoso N, Pediatric hospitalization associated with 2009 pandemic influenza A (H1N1) in Argentina. N Engl J Med. 2010;362:4555. DOIPubMed
  9. Gérardin P, Amrani RE, Cyrille B, Gagrièle M, Guillermin P, Boukerrou M, Low clinical burden of 2009 pandemic influenza A (H1N1) infection during pregnancy on the Island of La Réunion. PLoS ONE. 2010;5:e10896. DOIPubMed
  10. Japan Pediatric Society. Guideline for management of influenza (including pandemic [H1N1] 2009) in neonates during the early postnatal period in 2010–2011 season [in Japanese]. The Journal of Japan Pediatric Society. 2010;114:20168.

Suggested citation for this article: Takahashi N, Kitajima H, Kusuda S, Morioka I, Itabashi K. Pandemic (H1N1) 2009 in neonates, Japan [letter]. Emerg Infect Dis [serial on the Internet]. 2011 Sep [date cited]. http://dx.doi.org/10.3201/eid1709.101803

DOI: 10.3201/eid1709.101803

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Table of Contents – Volume 17, Number 9—September 2011

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Naoto Takahashi, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken 329-0498, Japan

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