Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients
Fadi Al Akhrass, Ray Hachem, Jamal A. Mohamed, Jeffrey Tarrand, Dimitrios P. Kontoyiannis, Jyotsna Chandra, Mahmoud Ghannoum, Souha Haydoura, Ann Marie Chaftari, and Issam Raad
Author affiliations: Author affiliations: The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (F. Al Akhrass, R. Hachem, J.A. Mohamed, J. Tarrand, D.P. Kontoyiannis, A.M. Chaftari, I. Raad); Case Western Reserve University, Cleveland, Ohio, USA (J. Chandra, M. Ghannoum); University Hospitals Case Medical Center, Cleveland (J. Chandra, M. Ghannoum); Kansas University School of Medicine, Wichita, Kansas, USA (S. Haydoura)
Figure 2. Antibiofilm agents inhibition of biomass of Nocardia nova complex biofilms. N. nova complex biofilms were grown for 24 h on silicone disks, placed in 24-well tissue culture plates, and exposed to trimethoprim/sulfamethoxazole (Bacterim) and heparin; trimethoprim, EDTA, and ethanol (EtOH); minocycline, EDTA, and ethanol; or Mueller-Hinton broth medium (control) for 2 h. Minocycline and trimethoprim-based lock solutions completely inhibited the N. nova complex biofilm biomass compared with controls (p = 0.003).
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.