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Volume 17, Number 9—September 2011

Letter

Highly Virulent Escherichia coli O26, Scotland

Kevin G.J. PollockComments to Author , Sheetal Bhojani, T. James Beattie, Lesley Allison, Mary Hanson, Mary E. Locking, and John M. Cowden
Author affiliations: Author affiliations: Health Protection Scotland, Glasgow, Scotland (K.G.J. Pollock, M.E. Locking, J.M. Cowden); Yorkhill Hospital, Glasgow (T.J. Beattie, S. Bhojani); Scottish E. coli O157/VTEC Reference Laboratory, Edinburgh, Scotland (L. Allison, M. Hanson)

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Table

Characteristics of infection in children with Escherichia coli O157 versus E. coli O26, Scotland, 2010*

Variable O157 HUS, n = 12 O26 HUS, n = 3 p value
Age, y
4.5 ± 1.0
3.7 ± 1.3

Clinical signs and symptoms
Diarrhea 12 3
Bloody diarrhea 8 (67) 2 (67) NS
Abdominal pain 8 (67) 3 (75) NS
Fever 2 (17) 1 (33) NS
Neurologic involvement 3 (25) 3 (100) 0.02
Diabetes 1 (12) 2 (67) 0.02
Cardiomyopathy 0 1 (33) 0.04
Anuria, d
7.7 ± 2.4
15.7 ± 1.3
0.04
Clinical parameters
Leukocyte count × 109/L 42.1 ± 14.4 25.9 ± 4.8 NS
C-reactive protein, mg/L 93.5 ± 28.4 151 ± 74 NS
Serum albumin, g/L 22.5 ± 1.3 22.3 ± 2.4 NS
Lactate dehydrogenase, IU/L
2,521 ± 362
1,991 ± 642
NS
Admission to ITU 3 (25) 3 (100) 0.04
Duration of hospitalization, d
13.2 ± 2.2
25 ± 3.8
0.03
Treatment
Peritoneal dialysis, d 7.4 ± 1.9 10 NS
Hemodialysis, d 8.5 ± 1.5 8.3 ± 3.0 NS
Hemofiltration 0 3 (100) 0.001
Laparotomy
0
1 (33)
0.04
Postdischarge hypertension 0 2 (67) 0.01

*Values are mean ± SE or no. (%). Significance relates to difference between groups. HUS, hemolytic uremic syndrome; NS, not significant, ITU, intensive treatment unit.

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