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Volume 17, Number 9—September 2011

Research

Estimating Effect of Antiviral Drug Use during Pandemic (H1N1) 2009 Outbreak, United States

Charisma Y. Atkins, Anita Patel, Thomas H. Taylor, Matthew Biggerstaff, Toby L. Merlin, Stephanie M. Dulin, Benjamin A. Erickson, Rebekah H. Borse, Robert Hunkler, and Martin I. Meltzer
Author affiliations: Author affiliations: Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.Y. Atkins, A. Patel, T.H. Taylor, Jr., M. Biggerstaff, T.L. Merlin, S.M. Dulin, B.A. Erikson, R.H. Borse, M.I. Meltzer); IMS Health, Fountain Hills, Arizona, USA (R. Hunkler)

Main Article

Table 1

Number of pandemic (H1N1) 2009 cases versus number of influenza antiviral prescriptions filled during pandemic (H1N1) 2009 outbreak, United States, April 24, 2009–March 26, 2010*

Week† Mid-level estimate of cases‡ Filled influenza antiviral prescriptions
Oseltamivir Zanamivir Total
2009 Apr–Jul 3,052,768 1,243,827 69,513 1,313,340
2009 Aug
1,605,760
342,386
11,645
354,031
35 626,256 146,282 5,097 151,379
36 1,675,630 234,211 7,171 241,382
37 1,302,846 265,626 7,892 273,518
38 1,508,514 331,060 8,735 339,795
39 2,319,691 383,759 9,981 393,740
40 4,461,542 435,546 11,625 447,171
41 6,549,205 471,323 11,226 482,549
42 7,120,298 527,362 11,218 538,580
43 6,297,210 671,741 12,046 683,787
44 5,899,647 640,887 9,306 650,193
45 5,013,181 537,781 6,338 544,119
46 3,350,286 386,569 4,863 391,432
47 1,767,166 273,092 3,039 276,131
48 1,020,606 152,482 1,857 154,339
49 804,901 133,998 1,782 135,780
50 646,358 99,565 1,348 100,913
51 612,204 88,718 1,338 90,056
52 619,080 64,807 1,010 65,817
1 418,803 56,569 1,009 57,578
2 520,390 50,642 981 51,651
3 516,958 50,326 1,057 51,307
4 356,400 44,770 1,048 45,827
5 493,448 43,757 1,211 44,805
6 322,623 42,474 1,251 43,685
7 312,327 43,809 1,228 45,060
8 281,986 47,146 1,487 48,374
9 245,707 48,671 1,494 50,158
10 288,215 47,261 1,587 48,755
11 225,448 33,867 1,043 34,910
12
312,575
26,072
730
26,802
Total 60,548,030 7,966,386 211,156 8,177,542

*IMS Health Xponent database (3) includes 57,544 oseltamivir prescriptions and 877 zanamivir prescriptions for week 53. Because the Centers for Disease Control and Prevention only reports 52 weeks for 2009, we removed week 53 from the IMS data set (IMS, Norwalk, CT, USA).
†Estimates of cases for April–August 2009 are not available on a weekly basis.
‡Mid-level weekly cases estimated from (1) and www.cdc.gov/h1n1flu/estimates_2009_h1n1.htm.

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