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Volume 18, Number 1—January 2012

Dispatch

Candida spp. with Acquired Echinocandin Resistance, France, 2004–20101

Eric Dannaoui2, Marie Desnos-Ollivier2, Dea Garcia-Hermoso, Fredéric Grenouillet, Sophie Cassaing, Marie-Thérèse Baixench, Stéphane Bretagne, Françoise Dromer, Olivier LortholaryComments to Author , and the French Mycoses Study Group
Author affiliations: Institut Pasteur, Paris, France (E. Dannaoui, M. Desnos-Ollivier, D. Garcia-Hermoso, S. Bretagne, F. Dromer, O. Lortholary); Centre Hospitalier Universitaire de Besançon, Besançon France (F. Grenouillet); Centre Hospitalier Universitaire de Toulouse–Hôpital Rangueil, Toulouse, France (S. Cassaing); Hôpital Cochin, Paris (M.-T. Baixench)

Main Article

Table 2

In vitro susceptibility and Fksp mutations of 20 echinocandin-resistant Candida spp. isolates, France, 2004–2010

Patient no.
Strain
Species
MIC, µg/m, AM3/RPMI 1640 medium
Fksp mutation
Caspofungin
Micafungin
Anidulafungin
Gene
Mutation
1* 05BL1-38 C. albicans 1/2 0.25/1 0.06/0.125 FKS1 (HS1) F641S
2* ODL13-1254 C. albicans 1/2 1/1 0.5/0.5 FKS1 (HS1) S645Y
3† 06BL2-127 C. albicans 2/2 1/0.5 0.125/0.125 FKS1 (HS1) F641S‡ + S645P‡
4 ODL19-1894 C. albicans 4/2 2/2 0.125/0.25 FKS1 (HS1) S645P
5* 08BL1-94 C. albicans 2/4 0.25/1 0.06/0.5 FKS1 (HS2) R1361G§
6* 08BL2-143 C. albicans 8/4 4/2 0.25/0.5 FKS1 (HS1) S645P
7* 09BL1-43 C. albicans 1/2 0.25/1 0.06/0.25 FKS1 (HS1) F641S
8* 09BL1-77 C. albicans 0.5/0.5 0.5/0.25 0.015/0.03 FKS1 (HS1) R647G§
9 06BL1-34 C. krusei 4/8 2/4 1/2 FKS1 (HS1) L648W§,¶
10* 10BL1-50 C. krusei 2/4 1/2 0.06/1 FKS1 (HS1) F645L§,¶
11 ODL7-647 C. glabrata 8/8 0.5/1 0.25/0.125 FKS2 DelF658#
12* 07BL2-157 C. glabrata 4/1 1/0.5 0.25/0.5 FKS2 DelF658#
13* 06BL1-33 C. glabrata 8/8 4/8 2/2 FKS2 S663P
14* ODL21-2028 C. glabrata 1/1 0.25/0.25 0.25/0.25 FKS1 S629P
15* ODL22-2183 C. glabrata 8/2 0.25/0.25 0.25/1 FKS2 S663P
16 ODL23-2221 C. glabrata 1/4 0.06/2 0.06/0.25 FKS1 + FKS2 F625I§ (FKS1) + P667T§ (FKS2)
17* 08BL2-142 C. glabrata 1/4 0.25/2 0.25/2 FKS2 S663P
18 09BL1-55 C. glabrata 8/4 2/4 0.5/0.5 FKS2 S663P
19 10BL1-19 C. glabrata 0.5/4 0.06/0.5 0.06/1 FKS2 F659S + L664V§
20 10BL1-67 C. glabrata 4/4 0.5/1 0.125/1 FKS2 DelF658#

*Parentage of initial isolate available.
†In this patient, another isolate with reduced susceptibility to echinocandin was retrieved. This isolate harbored an S645P mutation in FKS1.
‡Heterozygous mutation.
§Mutations not already described (13).
¶Strains had also an L701M mutation.
#Deletion.

Main Article

1This work was presented in part at the 20th European Congress of Clinical Microbiology and Infectious Diseases, Vienna, Austria, April 10–13, 2010 (abstract no. O346).

2These authors contributed equally to this article.

3Additional members of the French Mycoses Study Group who contributed data are listed at the end of this article.

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