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Volume 18, Number 1—January 2012

Dispatch

MRSA USA300 at Alaska Native Medical Center, Anchorage, Alaska, USA, 2000–2006

Michael Z. DavidComments to Author , Karen M. Rudolph, Thomas W. Hennessy, Diana L. Zychowski, Karthik Asthi, Susan Boyle-Vavra, and Robert S. Daum
Author affiliations: The University of Chicago, Chicago, Illinois, USA (M.Z. David, D.L. Zychowski, K. Asthi, S. Boyle-Vavra, R.S. Daum); Centers for Disease Control and Prevention, Anchorage, Alaska, USA (K.M. Rudolph, T.W. Hennessy)

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Table 2

MRSA isolate characteristics, combined retrospective and prospective collection samples by region of patient residence, Alaska, USA, 2000–2006*†

CC and ST No. (%) patients
Anchorage region, n = 97 Southwestern region, n = 56 Other regions, n = 71
CC1‡
ST1 25 (26) 43 (77) 10 (14)
CC5
ST5 11 (11) 2 (4) 16 (23)
ST105 1 (1) 2 (4) 9 (13)
ST225 0 0 1 (1)
ST231 0 1 (2) 1 (1)
CC8§
ST8 32 (33) 2 (4) 9 (13)
CC30
ST30 14 (14) 3 (5) 16 (23)
ST30slv 3 (3) 2 (4) 0
CC45
ST45 1 (1) 0 0
ST45slv 1 (1) 0 0
ST54 1 (1) 0 0
CC59
ST59 7 (7) 1 (2) 7 (10)
ST969 0 0 2 (3)
ST969slv 1 (1) 0 0
SCCmec type
II 10 (10) 4 (7) 29 (41)
IV 88 (91) 52 (93) 39 (55)
c-2.5 1 (1) 0 3 (4)

*MRSA, methicillin-resistant Staphyloccus aureus; CC, clonal complex; ST, sequence type; slv, single locus variant; SCCmec, staphylococcal cassette chromosome mec; PFGE, pulsed-field gel electrophoresis.
†Among 61 isolates genotyped from the prospective cohort, 18 were from inpatients (ST1 [n = 9], ST105 [n = 1], ST231 [n = 1], ST5 [n = 3], and ST8 [n = 4]), and 43 were from outpatients (ST1 [n = 14], ST105 [n = 1], ST30 [n = 2], ST30slv [n = 1], ST5 [n = 3], and ST8 [n = 22]).
‡CC1 has recently been changed to CC15 by the administrators of the multilocus sequence typing system. A randomly selected sample of 14 ST1 isolates that carried the SCCmec type IV element and were Panton-Valentine leukocidin positive underwent PFGE, and 93% (13/14) were USA400.
§42/43 ST8 strains identified in the study carried the SCCmec type IV element and were Panton-Valentine leukocidin positive. They are all considered to be USA300 because 30 of the 42 were randomly selected to undergo PFGE, and 100% (30/30) had the USA300 pulsotype.

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