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Volume 18, Number 1—January 2012

CME ACTIVITY - Research

Accelerating Control of Pertussis in England and Wales

Helen CampbellComments to Author , Gayatri Amirthalingam, Nick Andrews, Norman K. Fry, Robert C. George, Timothy G. Harrison, and Elizabeth Miller
Author affiliations: Health Protection Agency, London, UK

Main Article

Table 1

Changes in reported incidence of pertussis during 4-year periods before and after introduction of a fourth dose of pertussis vaccine, by age group, England and Wales, 1998–2009*

Age group and reporting mechanism Reported incidence, by year†
% Change per year, 1998–2009 (95% CI)‡
1998–2001 2002–2005 2006–2009
<3 mo
Laboratory reports 98.59 75.23 67.25 −4 (−9 to +1)
Notifications 103.65 64.83 53.77 −7 (−11 to −3)
Hospitalizations§ 268.16 156.20 123.14 −9 (−13 to −4)
3–5 mo
Laboratory reports 26.12 17.06 15.09 −6 (−11 to −2)
Notifications 57.94 34.44 31.94 −7 (−13 to −1)
Hospitalizations§ 84.57 41.74 34.56 −10 (−14 to −6)
6–11 mo
Laboratory reports 4.73 2.60 1.69 −11 (−17 to −5)
Notifications 19.59 7.72 12.09 −6 (−12 to +1)
Hospitalizations§ 16.53 9.32 5.63 −12 (−9 to −16)
1–4 y
Laboratory reports 1.65 1.05 0.87 −7 (−12 to −2)
Notifications 13.16 5.13 6.00 −9 (−16 to −2)
Hospitalizations§ 5.62 2.32 0.88 −19 (−23 to −16)
5–9 y
Laboratory reports 0.98 0.98 0.81 −3 (−7 to +2)
Notifications 8.02 3.67 3.44 −10 (−16 to −3)
Hospitalizations§ 2.07 0.79 0.13 −27 (−34 to −20)
10–14 y
Laboratory reports 0.33 0.69 3.10 +30 (+17 to +44)
Notifications 2.19 1.79 4.90 +9 (+1 to +19)
Hospitalizations§ 0.49 0.27 0.39 −3 (−11 to +4)
>15 y
Laboratory 0.02 0.18 0.82 +53 (+43 to +63)
Notifications 0.23 0.26 1.04 +18 (+9 to +28)
Hospitalizations§ 0.02 0.01 0.01 −1 (−7 to +6)

*Fourth dose introduced in October 2001.
†Rates per 100,000 population per year.
‡Calculated by linear regression analysis of the log of the annual incidence rate.
§Rates for England only.

Main Article

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