Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
Figure 2. Newly identified lpxL1 mutations XV, XVI, and XVII. lpxL1 sequence data from isolates harboring each of the corresponding meningococcal capsular group Y mutations (in parentheses), England and Wales. Mutations are aligned with the full-length gene from strain MC58. All of the alleles share a common start codon (green arrow). Mutations and stop codons are denoted by red circles and red lines, respectively. Mutation XVI is a single-base deletion at nt A4 that causes a frame shift resulting in a premature stop codon at nt 74. Mutation XVII is a single base deletion at nt T813. This causes a frame shift resulting in a late stop codon at nt 919. Mutation XV is a polymorphism at the region of the prototypical stop codon (that of strain MC58). In affected isolates, 3 adenines occupy the site that comprises the stop codon, TGA, in MC58. The next available stop codon occurs 15 bp downstream. The encoded peptide has an additional 6 aa.