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Volume 18, Number 1—January 2012

Research

Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009

Shamez N. LadhaniComments to Author , Jay Lucidarme, Lynne S. Newbold, Stephen J. Gray, Anthony D. Carr, Jamie Findlow, Mary E. Ramsay, Edward B. Kaczmarski, and Raymond Borrow
Author affiliations: Health Protection Agency, London, UK (S.N. Ladhani, M.E. Ramsay); Health Protection Agency, Manchester, UK (J. Lucidarme, L.S. Newbold, S.J. Gray, A.D. Carr, J. Findlow, E.B. Kaczmarski, R. Borrow); University of Manchester, Manchester (R. Borrow)

Main Article

Table A1

Molecular analysis of 114 MenY isolates causing invasive disease, England and Wales, 2007–2009*

Clonal complex Sequence type fhbp nhba FetA PorA lpxL1 mutation
23 (64)† 1655 (30) 2.25 (30) P0007 (30) 4-1 (30) P1.5-1,10-1,36-2 (18) XVI (18)
P1.5-1,10-4,36-2 (6) XVI (6)
P1.5-1,10-10,36-2 (3) XVI (3)
P1.5-1,10-1,25 (2) XVI (2)
P1.5-1,10-12,36-2 (1) XVI (1)
23 (22) 2.25 (20) P0006 (5) 5-8 (5) P1.5-1,2-2,36-2 (5) XV (3)
IV (1)
V (1)
P0007 (7) 4-1 (7) P1.5-1,10-4,36-2 (4) XVI (3)
V (1)
P1.5-2,10-1,25 (1) V (1)
P1.5-2,10-1,36-2 (2) V (1)
VI (1)
P0008 (8) 5-8 (7) P1.5-1,2-2,36-2 (5) V (5)
P1.5-1,2-2,25 (1) V (1)
NP (1) V (1)
1-7 (1) P1.5-1,2-2,36-2 (1) V (1)
2.104 (1) P0008 (1) 2-13 (1) P1.5-2,10-2,104 (1) I (1)
3.300 (1) P0007 (1) 4-1 (1) P1.5-2,10-1,36-2 (1) V (1)
183 (2) 2.104 (2) P0008 (2) NP (1) P1.5-2,10-2,36-2 (1) Intact (1)
4-1 (1) P1.5-2,10-2,36-2 (1) V (1)
8411 (2) 2.25 (2) P0006 (2) 5-8 (2) P1.5-1,2-2,36-2 (2) XV (2)
Other (7) 2.25 (4) P0007 (3) 4-1 (3) P1.5-1,10-4,36-2 (1) V (1)
P1.5-1,10-4,36-2 (1) XVI (1)
P1.5-2,10-1,36-2 (1) V (1)
P0008 (1) 5-8 (1) P1.5-1,2-2,36-2 (1) V (1)
2.104 (1) P0008 (1) 2-13 (1) P1.5-2,10-2,36-2 (1) XVII (1)
3.293 (1) P0007 (1) 4-1 (1) P1.5-2,10-1,36-2 (1) V (1)
1.335 (1) P0008 (1) 4-1 (1) P1.18-1,25,38-1 (1) Intact (1)
NK (1) 3.293 (1) P0007 (1) 4-1 (1) P1.5-2,10-1,36-2 (1) V (1)
174 (24) 1466 (20) 2.21 (18) P0006 (17) 3-7 (16) P1.21,16,37-1 (10) Intact (10)
P1.21,16,21 (1) Intact (1)
P1.22,9,35-1 (2) Intact (2)
P1.5-1,10-8,36-2 (2) Intact (1)
NK (1)
P1.7,30,38 (1) Intact (1)
2-16 (1) P1.5-1,2-2,36-2 (1) Intact (1)
P0242 (1) 3-7 (1) P1.22,9,35-1 (1) Intact (1)
1.13 (1) P0006 (1) 3-7 (1) P1.21,16,37-1 (1) Intact (1)
1.258 (1) P0006 (1) 3-7 (1) P1.21,16,37-1 (1) Intact (1)
7850 (2) 2.21 (2) P0006 (2) 3-7 (2) P1.21,16,21 (1) Intact (1)
P1.21,16,37-1 (1) Intact (1)
8413 (1) 2.21 (1) P0006 (1) 3-7 (1) P1.22,9,35-1 (1) Intact (1)
7263 (1) 2.21 (1) P0006 (1) 3-7 (1) P1.21,16,37-1 (1) Intact (1)
167 (12) 1627 (4) 2.23 (4) P0009 (4) 3-6 (4) P1.5-1,10-4,36-2 (2) Intact (2)
P1.5-1,10-8,36-2 (1) Intact (1)
P1.5-1,10-1,36-2 (1) Intact (1)
168 (3) 2.19 (2) P0009 (2) 3-1 (1) P1.5-1,10-4,36-2 (1) Intact (1)
5-2 (1) P1.5-1,10-4,36-2 (1) Intact (1)
2.23 (1) P0009 (1) 4-1 (1) P1.5-1,10-8,36-2 (1) Intact (1)
1624 (3) 2.23 (3) P0009 (3) 3-4 (3) P1.5-1,10-4,36-2 (3) Intact (3)
7921 (1) 2.16 (1) P0009 (1) 3-6 (1) P1.5-1,10-4,36-2 (1) Intact (1)
8420 (1) 2.23 (1) P0009 (1) 1-3 (1) P1.5-1,10-1,36-2 (1) Intact (1)
22 (9) 3651 (3) 2.25 (3) P0020 (3) 5-1 (3) P1.5-1,2-2,36-2 (2) Intact (2)
P1.5,2-2,36-2 (1) Intact (1)
114 (2) 2.16 (2) P0020 (2) 5-1 (2) P1.5-1,10-22,36-2 (2) Intact (2)
184 (1) 2.16 (1) P0020 (1) 3-9 (1) P1.18-1,3,38 (1) Intact (1)
1221 (1) 2.25 (1) P0020 (1) 1-7 (1) P1.18-1,3,38 (1) Intact (1)
2180 (1) 2.25 (1) P0020 (1) 1-2 (1) P1.18-1,3,38 (1) Intact (1)
2878 (1) 2.16 (1) P0020 (1) 4-1 (1) P1.18-1,3,38 (1) Intact (1)
Unassigned (3) 3015 (2) 2.16 (2) P0020 (2) 3-4 (1) P1.18-1,3,38 (1) Intact (1)
5-8 (1) P1.5-2,10-1,36-2 (1) Intact (1)
7786 (1) 2.16 (1) P0020 (1) 3-4 (1) NP (1) Intact (1)
92 (1) 5418 (1) 2.21 (1) P0009 (1) 4-1 (1) P1.5-1,10-22,36-2 (1) Intact (1)
103 (1) 103 (1) 2.25 (1) P0024 (1) 3-9 (1) P1.5-1,10-46,36-2 (1) Intact (1)

*MenY, meningococcal capsular group Y; fhbp , factor H binding protein (Novartis variant family.peptide); nhba, neisserial heparin-binding antigen; fetA, ferric enterochelin receptor variable region; porA, PorA variable regions (P1.VR1,VR2,VR3); lpxL1, acyl-transferase gene; NK, not known; NP, no product. Numbers in parentheses are the number of isolates.

†The sequence type for 1 clonal complex 23 strain was not available because of failure of existing primers to amplify the glucose-6-phosphate dehydrogenase (gdh) locus, but the remaining 6 loci were successfully characterized and were sufficient to assign the isolate to clonal complex 23.

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