Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
Figure 1. Structural details of neuraminidase mutations from pandemic (H1N1) 2009 viruses. A) Wildtype mutation I117 (green). B) mutation I117V (red). C) I117M (blue). All were modeled with FoldX (11) in YASARA (12) in the context of the pandemic (H1N1) 2009 virus neuraminidase crystal structure (Protein Data Bank: 3nss). Side chains of residues <3 Å of residue 117 are shown as sticks. Cavities within the structure (1.4 Å radius water probe) are shown in magenta.