Volume 18, Number 1—January 2012
Dispatch
Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model
Nadine Mestre-Francés
, Simon Nicot, Sylvie Rouland, Anne-Gaëlle Biacabe, Isabelle Quadrio, Armand Perret-Liaudet, Thierry Baron, and Jean-Michel Verdier
, Simon Nicot, Sylvie Rouland, Anne-Gaëlle Biacabe, Isabelle Quadrio, Armand Perret-Liaudet, Thierry Baron, and Jean-Michel VerdierTable
Experimental transmission of cattle-derived L-BSE agent to 12 mouse lemurs, by 2 routes of inoculation*
| Inoculation route | L-BSE dose, mg | Inoculated animals |
|||
|---|---|---|---|---|---|
| No. inoculated (no. alive) | Age at inoculation | Survival after inoculation, mo | Positive for PrPd † | ||
| Intracerebral | 5 | 4 | 1 y | 19; 19.5; 22; 22 | 4/4 |
| Oral | 50 | 3 (1‡) | 2 mo or 2 y | 18‡; 32 | 2/2 |
| Oral | 5 | 5 (2‡) | 2 mo or 2 y | 27; 33; 34 | 2/3 |
*L-BSE, L-type bovine spongiform encephalopathy source; PrPd, disease-associated prion protein. Source of L-BSE, 02–2528.
†Results obtained by Western blot analysis and/or paraffin-embedded tissue-blot analysis and/or immunohistochemical analysis.
‡Animals were inoculated at 2 y of age.
