Volume 18, Number 1—January 2012
Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model
|Inoculation route||L-BSE dose, mg||Inoculated animals
|No. inoculated (no. alive)||Age at inoculation||Survival after inoculation, mo||Positive for PrPd †|
|Intracerebral||5||4||1 y||19; 19.5; 22; 22||4/4|
|Oral||50||3 (1‡)||2 mo or 2 y||18‡; 32||2/2|
|Oral||5||5 (2‡)||2 mo or 2 y||27; 33; 34||2/3|
*L-BSE, L-type bovine spongiform encephalopathy source; PrPd, disease-associated prion protein. Source of L-BSE, 02–2528.
†Results obtained by Western blot analysis and/or paraffin-embedded tissue-blot analysis and/or immunohistochemical analysis.
‡Animals were inoculated at 2 y of age.