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Volume 18, Number 10—October 2012

Research

WU and KI Polyomaviruses in Respiratory Samples from Allogeneic Hematopoietic Cell Transplant Recipients

Jane Kuypers1Comments to Author , Angela P. Campbell1, Katherine A. Guthrie, Nancy L. Wright, Janet A. Englund, Lawrence Corey, and Michael Boeckh
Author affiliations: University of Washington, Seattle, Washington, USA (J. Kuypers, A.P. Campbell, N.L. Wright, J.A. Englund, L. Corey, M. Boeckh); Fred Hutchinson Cancer Research Center, Seattle (J. Kuypers, A.P. Campbell, K.A. Guthrie, J.A. Englund, L. Corey, M. Boeckh); and Seattle Children’s Hospital, Seattle (A.P. Campbell, J.A. Englund)

Main Article

Table 2

Characteristics of 222 HCT recipients tested for KIPyV or WUPyV*

Characteristic No. (%) recipients
All, n = 222 Infected with either virus, n = 62 Not infected, n = 160
Age, y

<20

23 (10) 18 (29) 5 (3)

20–39

37 (17) 14 (23) 23 (14)

40–59

99 (45) 17 (27) 82 (51)

>60

63 (28) 13 (21) 50 (31)
Sex

F

87 (39) 23 (37) 64 (40)

M

135 (61) 39 (63) 96 (60)
Underlying disease risk†

Standard

142 (64) 40 (65) 102 (64)

High

80 (36) 22 (35) 58 (36)
Stem cell source

Bone marrow

28 (13) 12 (19) 16 (10)

Peripheral blood

179 (81) 47 (76) 132 (83)

Cord blood

15 (7) 3 (5) 12 (8)
CMV serostatus

D+/R+

56 (25) 17 (27) 39 (24)

D+/R–

81 (36) 22 (35) 59 (37)

D–/R+

16 (7) 4 (6) 12 (8)

D–/R–

69 (31) 19 (31) 50 (31)
Donor match

Related–matched

77 (35) 23 (37) 54 (34)

Related–mismatched

9 (4) 6 (10) 3 (2)

Unrelated–cord blood

15 (7) 3 (5) 12 (8)

Unrelated–matched

97 (44) 24 (39) 73 (46)

Unrelated–mismatched

24 (11) 6 (10) 18 (11)
Conditioning regimen

Myeloablative

128 (58) 41 (66) 87 (54)

Nonmyeloablative

94 (42) 21 (34) 73 (46)
Acute graft-versus-host disease

Grade 0 or 1

78 (35) 30 (48) 48 (30)

Grade 2–4

144 (65) 32 (52) 112 (70)

*HCT, hematopoietic cell transplantation; KIPyV, KI polyomavirus; WUPyV, WU polyomavirus; CMV, cytomegalovirus; D, donor; R, recipient.
†The underlying disease stage of a patient was categorized as low, intermediate, or high risk (29,31).

Main Article

1These authors contributed equally to this article.

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