TY - JOUR AU - Rao, C. Durga AU - Yergolkar, Prasanna AU - Shankarappa, K. Subbanna T1 - Antigenic Diversity of Enteroviruses Associated with Nonpolio Acute Flaccid Paralysis, India, 2007–2009 T2 - Emerging Infectious Disease journal PY - 2012 VL - 18 IS - 11 SP - 1833 SN - 1080-6059 AB - Because of the broadened acute flacid paralysis (AFP) definition and enhanced surveillance, many nonpolio AFP (NP-AFP) cases have been reported in India since 2005. To determine the spectrum of nonpolio enterovirus (NPEV) serotypes associated with NP-AFP from polio-endemic and -free regions, we studied antigenic diversity of AFP-associated NPEVs. Of fecal specimens from 2,786 children with NP-AFP in 1 polio-endemic and 2 polio-free states, 823 (29.5%) were positive for NPEVs in RD cells, of which 532 (64.6%) were positive by viral protein 1 reverse transcription PCR. We identified 66 serotypes among 581 isolates, with enterovirus 71 most frequently (8.43%) detected, followed by enterovirus 13 (7.1%) and coxsackievirus B5 (5.0%). Most strains within a serotype represented new genogropups or subgenogroups. Agents for ≈35.0% and 70.0% of culture-positive and -negative cases, respectively, need to be identified. Association of human enterovirus with NP-AFP requires better assessment and understanding of health risks of NPEV infections after polio elimination. KW - Poliomyelitis KW - polio acute flaccid paralysis KW - non-polio acute flaccid paralysis KW - nonpolio enteroviruses KW - enterovirus-71 (EV-71) KW - coxsackievirus KW - echovirus KW - poliovirus KW - viruses KW - India KW - nonpolio acute flaccid paralysis KW - enterovirus 71 DO - 10.3201/eid1811.111457 UR - https://wwwnc.cdc.gov/eid/article/18/11/11-1457_article ER - End of Reference