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Volume 18, Number 11—November 2012

Research

Lack of Cross-protection against Bordetella holmesii after Pertussis Vaccination

Xuqing Zhang, Laura S. Weyrich, Jennie S. Lavine, Alexia T. Karanikas, and Eric T. HarvillComments to Author 
Author affiliations: The Pennsylvania State University, University Park, Pennsylvania, USA

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Figure 3

Results of testing of Bordatella pertussis and B. holmesii vaccines and protection against B. holmesii in mice. A) Mice vaccinated with whole-cell pertussis vaccine (wP) versus naive mice; B) mice vaccinated with aceullar pertussis vaccine (aP) versus adjuvant (adj) only vaccinated; C) mice vaccinated with whole-cell B. holmesii vaccine (wH) versus naive mice. All mice were challenged with B. pertussis (B.p.), B. parapertussis (B.p.p.) or B. holmesii (B.h.), and euthanized on day 3 postinoculati

Figure 3. . . . Results of testing of Bordatella pertussis and B. holmesii vaccines and protection against B. holmesii in mice. A) Mice vaccinated with whole-cell pertussis vaccine (wP) versus naive mice; B) mice vaccinated with aceullar pertussis vaccine (aP) versus adjuvant (adj) only vaccinated; C) mice vaccinated with whole-cell B. holmesii vaccine (wH) versus naive mice. All mice were challenged with B. pertussis (B.p.), B. parapertussis (B.p.p.) or B. holmesii (B.h.), and euthanized on day 3 postinoculation. Error bars indicate SE. *p≤0.05; †p≤0.01.

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