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Volume 18, Number 11—November 2012

Research

HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina

Viviana RitaccoComments to Author , Beatriz López, Marta Ambroggi, Domingo Palmero, Bernardo Salvadores, Elida Gravina, Eduardo Mazzeo, Susana Imaz, Lucía Barrera, and National TB Laboratory Network
Author affiliations: Instituto Nacional de Enfermedades Infecciosas ANLIS “Dr. Carlos G. Malbrán,” Buenos Aires, Argentina (V. Ritacco, B. López, E. Mazzeo, L. Barrera); Hospital “Dr. F.J. Muñiz,” Buenos Aires (M. Ambroggi, D. Palmero); Programa Provincial de Tuberculosis, Santa Fe, Argentina (B. Salvadores); Hospital Zonal General Agudos “Dr. Diego Paroissien,” La Matanza, Argentina (E. Gravina); and Instituto Nacional de Enfermedades Respiratorias “Dr. Emilio Coni” ANLIS “Dr Carlos G Malbran,” Santa Fe (S. Imaz)

Main Article

Table 5

Predictors for being in cluster M among 438 patients with multidrug-resistant TB who were in clusters of >15 patients, Argentina, 2003–2009*

Characteristic No. patients % Patients in M cluster Unadjusted OR (95% CI) Adjusted OR (95% CI)†
Age, y, n = 347

16–45

288 50.7 0.9 (0.5–1.6) 1.4 (0.5–4.3)

>45

59 52.5 1 1
Country of birth, n = 302

Argentina

275 51.0 0.7 (0.3–1.6) 0.6 (0.1–2.3)

Other

27 74.1 1 1
HIV status, n = 360

Positive

194 60.3 1.6 (1.0–2.4) 1.4 (0.6–3.3)

Negative

166 49.4 1 1
Previous TB treatment, n = 304

Yes

160 47.5 1.0 (0.7–1.6) 0.8 (0.4–1.8)

No

144 46.5 1 1
Hospital exposure‡

Yes

86 72.1 2.9 (1.7–4.8) 2.6 (1.0–6.8)

No

352 47.2 1 1
Isolate resistant to

>5 drugs

207 88.4 31.5 (18.4–53.9) 22.7 (10.1–50.9)

<5 drugs

231 19.5 1 1

*Boldface indicates significance. TB, tuberculosis; OR, odds ratio.
†Overall model fit p < 0.0001. Hosmer & Lemeshow test p = 0.899, area under the receiver operating characteristic curve 0.854.
‡Previous hospitalization(s), concomitant condition, or health care worker.

Main Article

1Additional members of the National TB Laboratory Network who contributed data are listed at the end of this article.

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