TY - JOUR AU - Nunes, Marcio Roberto Teixeira AU - Faria, Nuno Rodrigues AU - Vasconcelos, Helena Baldez AU - Medeiros, Daniele Barbosa de Almeida AU - Silva de Lima, Clayton Pereira AU - Carvalho, Valéria Lima AU - Pinto da Silva, Eliana Vieira AU - Cardoso, Jedson Ferreira AU - Sousa, Edivaldo Costa AU - Nunes, Keley Nascimento Barbosa AU - Rodrigues, Sueli Guerreiro AU - Abecasis, Ana Barroso AU - Suchard, Marc AU - Lemey, Philippe AU - Vasconcelos, Pedro Fernando da Costa T1 - Phylogeography of Dengue Virus Serotype 4, Brazil, 2010–2011 T2 - Emerging Infectious Disease journal PY - 2012 VL - 18 IS - 11 SP - 1858 SN - 1080-6059 AB - Dengue virus serotype 4 (DENV-4) reemerged in Roraima State, Brazil, 28 years after it was last detected in the country in 1982. To study the origin and evolution of this reemergence, full-length sequences were obtained for 16 DENV-4 isolates from northern (Roraima, Amazonas, Pará States) and northeastern (Bahia State) Brazil during the 2010 and 2011 dengue virus seasons and for an isolate from the 1982 epidemic in Roraima. Spatiotemporal dynamics of DENV-4 introductions in Brazil were applied to envelope genes and full genomes by using Bayesian phylogeographic analyses. An introduction of genotype I into Brazil from Southeast Asia was confirmed, and full genome phylogeographic analyses revealed multiple introductions of DENV-4 genotype II in Brazil, providing evidence for >3 introductions of this genotype within the last decade: 2 from Venezuela to Roraima and 1 from Colombia to Amazonas. The phylogeographic analysis of full genome data has demonstrated the origins of DENV-4 throughout Brazil. KW - dengue virus KW - serotype 4 KW - molecular epidemiology KW - phylogeography KW - Brazil KW - viruses KW - reemergence. genetic characterization KW - spatiotemporal patterns KW - reemergence KW - genetic characterization DO - 10.3201/eid1811.120217 UR - https://wwwnc.cdc.gov/eid/article/18/11/12-0217_article ER - End of Reference