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Volume 18, Number 12—December 2012

Dispatch

Reemergence of Chikungunya Virus in Cambodia

Veasna Duong, Anne-Claire Andries, Chantha Ngan, Touch Sok, Beat Richner, Nima Asgari-Jirhandeh, Steve Bjorge, Rekol Huy, Sovann Ly, Denis Laurent, Bunheng Hok, Maria Concepcion Roces, Sivuth Ong, Meng Chuor Char, Vincent Deubel, Arnaud Tarantola, and Philippe BuchyComments to Author 
Author affiliations: Author affiliations: Institut Pasteur in Cambodia, Phnom Penh, Cambodia (V. Duong, A.-C. Andries, S. Ong, V. Deubel, A. Tarantola, P. Buchy); Ministry of Health, Phnom Penh (C. Ngan, T. Sok, R. Huy, S. Ly, M.C. Char,); Jayavarman VII Hospital, Siem Reap, Cambodia (B. Richner, D. Laurent); World Health Organization, Phnom Penh (N. Asgari-Jirhandeh, S. Bjorge, M.C. Roces); Preah Vihear Provincial Health Department, Preah Vihear, Cambodia (B. Hok)

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Table

Characteristics of 24 patients with positive results for chikungunya virus, Cambodia, 2011*

Patient no. Project Age, y/sex Date of symptom onset Date sampled Province Initial syndrome reported IgM-capture ELISA

RT-PCR
Full-genome
sequencing
1st 2nd Serum SN
V0603308 NDCP 2/M May 26 May 28 BTB Dengue† Neg Pos Pos Pos Partial
V0603310 NDCP 4/F May 26 May 28 BTB Dengue Neg Pos Pos Pos Complete
V0705309 CNS 5/M Jun 23 Jun 30 SRP Encephalitis‡ Neg Pos Neg Neg ND
V0719309 CNS 14/M Jul 9 Jul 17 SRP Encephalitis Pos Pos Neg Neg ND
V0719310 CNS 7/M Jul 10 Jul 13 KTH Encephalitis Pos Pos Pos Neg ND
V1005304 NDCP 15/M Sep 30 Oct 4 KCH Dengue Neg Pos Pos Pos ND
V1024306 CDC 11/F Aug 10 Aug 16 PVH Measles§ Neg NA Pos Neg Complete
V1024307 CDC 11/F Aug 15 Aug 16 PVH Measles Pos NA Neg Neg ND
V1024308 CDC 28/F Aug 8 Aug 16 PVH Measles Neg NA Pos Neg Complete
V1024309 CDC 30/F Aug 8 Aug 16 PVH Measles Pos NA Pos Pos ND
V1024310 CDC 17/M Aug 13 Aug 16 PVH Measles Neg NA Pos Pos Complete
V1024311 CDC 2.5/F Aug 16 Aug 16 PVH Measles Neg NA Pos Pos Complete
V1024312 CDC 13/F Aug 16 Aug 16 PVH Measles Neg NA Pos Pos ND
V1024313 CDC 10/F Aug 14 Aug 16 PVH Measles Neg NA Pos Pos Complete
V1024314 CDC 31/F Aug 15 Aug 16 PVH Measles Neg NA Pos Pos Complete
V1214306 NMC 49/M Dec 9 Dec 9 PVH Dengue Neg NA Pos Neg ND
V1214307 NMC 56/M Dec 6 Dec 9 PVH Dengue Neg NA Pos Neg ND
V1214308 NMC 29/M Dec 5 Dec 9 PVH Dengue Neg NA Pos Pos ND
V1214309 NMC 39/F Dec 9 Dec 10 PVH Dengue Neg NA Pos Pos ND
V1214310 NMC 17/F Dec 9 Dec 10 PVH Dengue Neg NA Pos Pos ND
V1214311 NMC 27/M Dec 7 Dec 10 PVH Dengue Pos NA Neg Neg ND
V1214312 NMC 16/M Dec 9 Dec 10 PVH Dengue Neg NA Pos Pos ND
V1214333 NMC 30/F NA Dec 10 PVH Dengue Neg NA Pos Pos ND
V1207304 NDCP 9/F Dec 1 Dec 6 KAN Dengue Pos Pos Neg Neg ND

*All patients had negative IgM-capture ELISA results for flaviviruses (dengue 1–4, Japanese encephalitis, Langat) and other alphaviruses (Sindbis).
RT-PCR, real-time reverse transcription PCR; 1st, acute-phase serum sample; 2nd, convalescent-phase serum sample; SN, supernatant; NDCP: National Dengue Control Program, National Malaria Center, Ministry of Health; BTB, Battambang; Neg, negative; Pos, positive; CNS, central nervous system infection (encephalitis) study; SRP: Siem Reap; ND, not done; KTH: Kampong Thom; KCH: Kampong Cham; CDC, Communicable Disease Control Department, Ministry of Health, Preah Vihear outbreak investigation in August 2011; PVH: Preah Vihear; NA, not available; NMC, National Malaria Center, Ministry of Health, Preah Vihear outbreak investigation in December 2011; KAN, Kandal.
†Dengue-like: fever with headache, retro-orbital pain, myalgia, joint pain, and/or hemorrhage.
‡Encephalitis: fever with convulsion, vomiting, and/or hemiplegia.
§Measle-like: fever with rash, cough, or join pain.

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