TY - JOUR AU - Feng, Jinling AU - Hu, Yanxin AU - Ma, Zhijun AU - Yu, Qi AU - Zhao, Jixun AU - Liu, Xiaodong AU - Zhang, Guozhong T1 - Virulent Avian Infectious Bronchitis Virus, People’s Republic of China T2 - Emerging Infectious Disease journal PY - 2012 VL - 18 IS - 12 SP - 1994 SN - 1080-6059 AB - A virulent avian infectious bronchitis virus (IBV) was isolated from 30-day-old broiler chickens that exhibited respiratory symptoms, nephropathologic lesions, and a high proportion of deaths in the People’s Republic of China during 2005. The strain, designated YN, was genetically and pathologically characterized. Phylogenetic analysis showed that YN and most of the previously characterized IBV isolates found in China were phylogenetically classified into 2 main genetic clusters. The YN isolate caused severe lesions and resulted in deaths of 65% in experimental infections of 30-day-old specific-pathogen–free chickens. Tracheal and severe kidney lesions developed in all infected birds, confirming the ability of YN strain to induce both respiratory and renal disease. IBV antigens were detected by immunohistochemical analysis in the trachea, lung, kidney, and bursa, consistent with histopathologic observations, virus isolation, and reverse transcription PCR detection. We showed that YN IBV exhibits severe pathogenicity in chickens, and that similar viruses are prevalent in China. KW - Avian infectious bronchitis virus KW - virulence KW - pathogenicity KW - tissue tropism KW - phylogenetic analysis KW - viruses KW - People’s Republic of China KW - chickens KW - China DO - 10.3201/eid1812.120552 UR - https://wwwnc.cdc.gov/eid/article/18/12/12-0552_article ER - End of Reference