Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 18, Number 12—December 2012

Research

Diagnostic Assays for Crimean-Congo Hemorrhagic Fever

Jessica VanhomwegenComments to Author , Maria João Alves, Tatjana Avšič Županc, Silvia Bino, Sadegh Chinikar, Helen Karlberg, Gülay Korukluoğlu, Miša Korva, Masoud Mardani, Ali Mirazimi, Mehrdad Mousavi, Anna Papa, Ana Saksida, Batool Sharifi-Mood, Persofoni Sidira, Katerina Tsergouli, Roman Wölfel, Hervé Zeller, and Philippe Dubois
Author affiliations: Author affiliations: Institut Pasteur, Paris, France (J. Vanhomwegen, P. Dubois); European Centre for Disease Control, Stockholm, Sweden (J. Vanhomwegen, H. Zeller); National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal (M.J. Alves); Faculty of Medicine, Ljubljana, Slovenia (T. Avšič Županc, M. Korva, A. Saksida); Institute of Public Health, Tirana, Albania (S. Bino); Pasteur Institute of Iran, Tehran, Iran (S. Chinikar); Swedish Institute for Infectious Disease Control, Solna, Sweden (H. Karlberg, A. Mirazimi, M. Mousavi); Refik Saydam National Public Health Agency, Ankara, Turkey (G. Korukluoğlu); Shahid Beheshti University of Medical Sciences, Tehran, Iran (M. Mardani, B. Sharifi-Mood); Aristotle University of Thessaloniki, Thessaloniki, Greece (A. Papa, P. Sidira, K. Tsergouli); and Bundeswehr Institute of Microbiology, Munich, Germany (R. Wölfel)

Main Article

Table 3

Patient characteristics and sample storage information for samples tested for CCHFV

CCHFV positive, n = 66 CCHFV negative, n = 73 CCHFV positive, n = 54 CCHFV negative, n = 21
Conditions

CCHF

66 (100.0) 0 54 (100.0) 0

Brucellosis

0 2 (2.7) 0 2 (9.5)

Chikungunya

0 1 (1.4) 0 1 (4.8)

HFRS

0 13 (17.8) 0 7 (33.3)

Leptospirosis

0 13 (17.8) 0 3 (14.3)

Q fever

0 1 (1.4) 0 1 (4.8)

Tularemia

0 1 (1.4) 0 1 (4.8)

West Nile fever

0 1 (1.4) 0 1 (4.8)

Healthy or non-CCHF

0 41 (56.2) 0 5 (23.8)
Patient country of origin

Albania

9 (13.6) 0 8 (14.8) 0

Germany

0 23 (31.5) 0 7 (33.3)

Greece

0 9 (12.3) 0 9 (42.9)

Iran

32 (48.5) 0 31 (57.4) 0

Kosovo

21 (31.8) 20 (27.4) 7 (13.0) 4 (19.0)

Portugal

0 20 (27.4) 0 0

Sub-Saharan Africa

4 (6.1) 0 0 0

Turkey

0 1 (1.4) 8 (14.8) 1 (4.8)
CCHF disease severity

Moderate

49 (74.2) 0 37 (68.5) 0

Severe

11 (16.7) 0 2 (3.7) 0

Fatal

3 (4.5) 0 6 (11.1) 0

Asymptomatic

3 (4.5) 0 7 (13.0) 0

Unknown

0 0 2 (3.7) 0
Length of illness, d

<15 d

46 (69.7) 0 43 (79.6) 0

≥15 d

12 (18.2) 0 0 0

Asymptomatic

3 (4.5) 0 7 (13.0) 0

Unknown

5 (7.6) 0 4 (7.4) 0
Sample storage time, y

<10

49 (74.2) 64 (87.7) 54 (100.0) 10 (47.6)

≥10

17 (25.8) 0 0 2 (9.5)

Unknown

0 9 (12.3) 0 9 (42.9)
Sample storage temperature, °C

−80

34 (51.5) 49 (67.1) 9 (16.7) 4 (19.1)

−70

32 (48.5) 0 45 (83.3) 9 (42.9)

−20

0 24 (32.9) 0 8 (38.1)

*CCHF, Crimean-Congo hemorrhagic fever; CCHFV, CCHF virus; HFRS, hemorrhagic fever with renal syndrome.

Main Article

TOP