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Volume 18, Number 12—December 2012

Research

Transmission Routes for Nipah Virus from Malaysia and Bangladesh

Bronwyn A. Clayton, Deborah Middleton, Jemma Bergfeld, Jessica Haining, Rachel Arkinstall, Linfa Wang, and Glenn A. MarshComments to Author 
Author affiliations: Author affiliations: Commonwealth Scientific and Industrial Research Organisation Livestock Industries, Geelong, Victoria, Australia (B.A. Clayton, D. Middleton, J. Bergfeld, J. Haining, R. Arkinstall, L. Wang, G.A. Marsh); University of Melbourne, Parkville, Victoria, Australia (B.A. Clayton); Duke–National University of Singapore Graduate Medical School, Singapore (L. Wang)

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Table 5

Histopathologic and immunohistochemical findings in major systems of ferrets infected with NiV from Bangladesh or Malaysia*

System, predominant lesion No. animals with lesion/antigen/vasculitis†
NiV-Bangladesh, n = 8 NiV-Malaysia, n = 7
Respiratory

Acute rhinitis

7/5/1 6/7/0

Acute bronchoalveolitis


8/8/1
7/7/4
Lymphoid

Lymphadenitis

8/8/1 7/7/0

Splenic necrosis


7/7/1
6/7/1
Renal, glomerular necrosis
8/6/0
6/7/1
Hepatic, focal hepatic necrosis
8/7/0
1‡/2/0
Central nervous

Meningitis

0/4/0 2/5/1

Encephalitis

0/7/0 0/3/0

*NiV, Nipah virus.
†No. animals in which the predominant lesion was observed/antigen staining was observed in that organ or tissue/vasculitis was present in that organ or tissue. For all animals, vasculitis was associated with antigen staining in blood vessel endothelium or tunica media.
‡This animal also had cholecystitis with associated viral antigen.

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