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Volume 18, Number 2—February 2012

CME ACTIVITY - Research

Invasive Pneumococcal Disease and Pandemic (H1N1) 2009, Denver, Colorado, USA

George E. NelsonComments to Author , Kenneth A. Gershman, David L. Swerdlow, Bernard W. Beall, and Matthew R. Moore
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (G.E. Nelson, D.L. Swerdlow, B.W. Beall, M.R. Moore); Colorado Department of Health and the Environment, Denver, Colorado, USA (K.A. Gershman)

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Table 1

Epidemiologic characteristics of patients with invasive pneumococcal disease, Denver, Colorado, USA, February and October 2009*

Characteristic Patients with pandemic (H1N1) 2009, Oct 2009, n = 58 Patients with seasonal influenza, Feb 2009, n = 45 p value
Age, y
0–<5 6 (10) 0 (0) NC
5–19 3 (5) 3 (7) NC
20–39 10 (17) 6 (13) NC
40–59 26 (45) 17 (38) NC
>60 13 (22) 19 (42) NC
Median age (range 2 mo–91 y) 45 54 0.02
Sex 0.120
M 38 (66) 26 (58) NC
F 20 (34) 16 (36) NC
Unknown 0 3 (7) NC
Race† 0.012
White 31 (53) 11 (24) NC
African American 4 (7) 3 (7) NC
Asian 0 (0) 2 (4) NC
Unknown 23 (40) 29 (64) NC
Ethnicity† <0.0001
Hispanic 14 (24) 7 (16) NC
Non-Hispanic 25 (43) 4 (9) NC
Unknown 19 (33) 34 (76) NC
Concurrent condition‡ NC
Any 40 (69) 17 (38) <0.0001
Chronic lung disease 17 (29) 3 (7) 0.0002
Diabetes 5 (9) 6 (13) 0.852
HIV infection 2 (3) 0 (0) 0.247
Liver disease 5 (8.6) 2 (4) 0.276
Smoking 15 (26) 10 (22) 0.669
Hospitalized
Yes 54 (93) 36 (80) 0.536
No 4 (7) 2(4) NC
Unknown 0 7 (16) NC
Tested for influenza§ 47 (81) NA NC
Outpatient setting 8 NA NC
Inpatient setting 43 NA NC
Positive test result for influenza§ 10 NA NC

*Values are no. (%) unless otherwise indicated. NA, not available; NC, not calculated.
†Race and ethnicity data required additional patient consent.
‡Underlying concurrent condition comparisons were adjusted for age.
§Includes data from supplemental case report form not available for prior years.

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