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Volume 18, Number 2—February 2012

Research

Unsuspected Dengue and Acute Febrile Illness in Rural and Semi-Urban Southern Sri Lanka

Megan E. RellerComments to Author , Champika Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara-Arachichi, John J. Strouse, Anne Broadwater, Truls Østbye, Aravinda de Silva1, and Christopher W. Woods1
Author affiliations: Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (M.E. Reller, J.J. Strouse); Medical Faculty of University of Ruhuna, Galle, Sri Lanka (C. Bodinayake, A. Nagahawatte, V. Devasiri, W. Kodikara-Arachichi); University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA (A. Broadwater, A. de Silva); Duke University School of Medicine, Durham, North Carolina, USA (T. Østbye, C.W. Woods)

Main Article

Table 1

Clinical characteristics of febrile patients with and without acute dengue, southern Sri Lanka, 2007*

Characteristic Acute dengue, n = 54 Not acute dengue, n = 805 p value
Symptoms
Headache 75.9 78.1 0.70
Sore throat 13.0 29.3 0.01
Cough 35.2 58.5 0.001
Dyspnea 15.1 16.7 0.76
Joint pain 50.9 44.3 0.35
Muscle pain 57.7 48.7 0.21
Lethargy 68.6 66.6 0.76
Abdominal pain 25.0 19.0 0.29
Emesis 43.4 36.9 0.35
Diarrhea 22.2 10.7 0.01
Dysuria 16.7 14.4 0.65
Oliguria 14.8 9.1 0.17
Signs
Mean temperature, °C, ± SD 38.5 ± 0.70 38.4 ± 0.61 0.66
Mean heart rate, beats/min, ± SD 85 ± 17 84 ± 16 0.57
Mean systolic blood pressure, mm Hg, ± SD 114 ± 16 111 ± 16 0.32
Mean diastolic blood pressure, mm Hg, ± SD 72 ± 16 73 ± 11 0.58
Conjunctivitis 27.8 14.0 0.006
Pharyngeal erythema or exudates 5.6 14.0 0.08
Lymphadenopathy 3.7 24 0.001
Jaundice 7.6 1.4 0.001
Lung crackles 5.7 14.2 0.08
Tender abdomen on palpation 18.5 9.4 0.03
Hepatomegaly 11.3 5.0 0.05
Swollen joint 1.9 0.5 0.27
Rash 5.6 2.3 0.14
Laboratory parameters
Leukocytes/μL, median (IQR) 5,300 (3,600–12,000) 8,000 (5,800–11,100) 0.009
ANC/μL, median (IQR) 3,600 (2,304–8,560) 5,396 (3,534–7,980) 0.03
ALC/μL, median (IQR) 1,602 (1,044–2,400) 2,085 (1,540–2,829) 0.002
Hemoglobin, g/dL, mean ± SD 12.9 ± 1.6 12.6 ± 1.7 0.25
Platelets, × 1,000/μL, mean (IQR) 190 (156–242) 232 (190–293) 0.0002

*Values are percentages unless otherwise stated. Leukocytes, white blood cell count; ANC, absolute neutrophil count; ALC, absolute lymphocyte count; IQR, interquartile range.

Main Article

1These authors contributed equally to this article.

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