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Volume 18, Number 2—February 2012

Research

Pathogenesis of Avian Bornavirus in Experimentally Infected Cockatiels

Anne K. PiepenbringComments to Author , Dirk Enderlein, Sibylle Herzog, Erhard F. Kaleta, Ursula Heffels-Redmann, Saskia Ressmeyer, Christiane Herden, and Michael Lierz
Author affiliations: Justus Liebig University Giessen, Giessen, Germany

Main Article

Table 2

Postmortem findings in cockatiels experimentally infected with ABV*

Bird Died, dpi Euthanized, dpi Antibody titer† Dilatation of proventriculus‡ Antigen detection§
Infectious virus¶
p14 p24
ic1 10,240 2 + + +
ic2 206 5,120 3 + + +
ic3 60 20,480 1 + + +
ic4 115 20,480 0 + + +
ic5 115 20,480 0 + + +
ic6 230 5,120 0 + + +
ic7 66 1,0240 0 + + +
ic8 230 1,0240 0 + + +
ic9 115 5,120 0 + + +
iv1 230 10,240 2 + + +
iv2 229 5,120 2 + + +
iv3 120 10,240 2 + +
iv4 116 5,120 1 + + +
iv5 116 20,480 0 + + +
iv6 229 10,240 0 + + +
iv7 229 10,240 0 + + +
iv8 116 5,120 0 + + +
iv9 229 20,480 0 + + +
se1 229 <10 0

*Proventricular dilatation disease was confirmed in all birds by histopathologic confirmation of lymphoplasmacytic infiltrates of/near ganglia in the central nervous system and/or upper gastrointestinal tract. ABV, avian bornavirus; dpi, days postinoculation; ic, intracerebrally inoculated; +, positive; −, negative; iv, intravenously inoculated; se, sentinel.
†Antibodies against avian bornavirus detected by use of indirect immunofluorescence assay; titers <10.0 are considered negative.
‡0, no dilatation; 1, mild dilatation; 2, moderate dilatation; 3, severe dilatation.
§Detection of the X-protein (p14) and the phosphoprotein (p24) of Borna disease virus by immunohistochemical testing.
¶Re-isolation of infectious ABV in quail cell line CEC-32.

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