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Volume 18, Number 3—March 2012

Dispatch

Drug-Resistant Tuberculosis in Zhejiang Province, China, 1999–2008

Xiaomeng Wang, Qian Fu, Zhijun Li, Songhua Chen, Zhengwei Liu, Hugh Nelson, Qun Yang, Zhongwei JiaComments to Author , and Christopher Dye
Author affiliations: Center for TB Control in Zhejiang, Hangzhou, People’s Republic of China (X. Wang, S. Chen, Z. Liu); Capital Medical University, Beijing, People’s Republic of China (Q. Fu, Q. Yang); National Research Institute of Food and Fermentation Industries, Beijing (Z. Li); International SOS Clinic, Shekou, People’s Republic of China (H. Nelson); Peking University, Beijing (Z. Jia); World Health Organization, Geneva, Switzerland (C. Dye)

Main Article

Table 2

Factors associated with resistance to tuberculosis drugs, Zhejiang Province, China, 1999–2008*

Characteristic Coefficient OR (95% CI) p value
Model 1: Risk factors associated with resistance to isoniazid
    Constant −4.10 0.02
    Year 0.23 1.26 (0.87–1.84) 0.221
    Rifampin 2.99 19.91 (12.91–30.70) <0.001
    Age 0–14 years 0.89 2.43 (0.20–34.90) 0.51
    Age 15–64 years −0.49 0.61 (0.40–0.94) <0.05
    Sex 0.16 1.17 (0.80–1.71) 0.43
    Re-treatment 0.62 1.85 (1.24–2.76) <0.005
Model 2: Risk factors associated with resistance to rifampin
    Constant −3.33 0.10 <0.001
    Year −0.53 0.59 (0.38–0.93) <0.05
    Isoniazid 2.99 19.85 (12.92–30.51) <0.001
    Age 0–14 year −1.74 0.18 (0.02–1.29) 0.09
    Age 15–64 year −0.05 1.02 (0.62–1.66) 0.95
    Sex −0.30 0.73 (0.47–1.16) 0.19
    Re-treatment 1.84 6.29 (4.15–9.53) <0.001
Model 3: Risk factors associated with MDR TB
    Constant −2.78 0.62 <0.001
    Year −0.16 0.86 (0.61–1.21) 0.384
    Age 0–14 year −0.69 0.52 (0.06–4.36) 0.56
    Age 15–64 year −0.45 0.62 (0.40–0.96) <0.05
    Sex −0.17 0.86 (0.58–1.23) 0.37
    Re-treatment 2.20 9.01 (6.39–12.68) <0.001

*Reference groups are >65 years for age, female for sex, and new for re-treatment. OR, odds ratio; MDR TB, multidrug-resistant tuberculosis.

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