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Volume 18, Number 4—April 2012
Dispatch

Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

Jurriaan E.M. de SteenwinkelComments to Author , Marian T. ten Kate, Gerjo J. de Knegt, Kristin Kremer, Rob E. Aarnoutse, Martin J. Boeree, Henri A. Verbrugh, Dick van Soolingen, and Irma A.J.M. Bakker-Woudenberg
Author affiliations: Erasmus University Medical Center, Rotterdam, the Netherlands (J.E.M. de Steenwinkel, M.T. ten Kate, G.J. de Knegt, H.A. Verbrugh, I.A.J.M. Bakker-Woudenberg); National Institute of Public Health and the Environment Center for Infectious Disease Control (RIVM),; Bilthoven, the Netherlands (K. Kremer, D. van Soolingen); World Health Organization Regional Office for Europe, Copenhagen, Denmark (K. Kremer); Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (R.E. Aarnoutse, M.J. Boeree, D. van Soolingen)

Main Article

Table 1

Mutation frequency of Mycobacterium tuberculosis genotype strains originating from Vietnam, by antituberculosis drug

Genotype Frequency of mutation among strains*
Isoniazid Rifampin Moxifloxacin Amikacin
Beijing
1585 5.7 × 10−6, 6.2 × 10−6 3.0 × 10−3, 4.3 × 10−3 4.3 × 10−8, 6.1 × 10−8 2.3 × 10−8, 3.2 × 10−8
1607 8.6 × 10−6, 1.4 × 10−5 1.5 × 10−3, 5.4 × 10−3 6.9 × 10−8, 2.4 × 10−7 8.6 × 10−8, 3.0 × 10−7
2115 7.3 × 10−6, 1.1 × 10−5 1.0 × 10−3, 9.2 × 10−5 1.0 × 10−8, 4.3 × 10−8 1.4 × 10−8, 2.8 × 10−8
2121 6.8 × 10−5, 2.9 × 10−4 2.9 × 10−5, 1.9 × 10−4 1.1 × 10−7, 1.6 × 10−7 9.3 × 10−8, 1.1 × 10−7
2145 9.1 × 10−4, 5.0 × 10−4 1.6 × 10−5, 5.5 × 10−5 7.9 × 10−8, 1.0 × 10−7 7.6 × 10−7, 1.1 × 10−6
East-African/Indian
1627 3.7 × 10−6, 6.5 × 10−6 4.1 × 10−6, 2.8 × 10−6 9.3 × 10−9, 1.5 × 10−7 5.6 × 10−8, 4.5 × 10−9
1606 8.7 × 10−6, 1.6 × 10−4 3.8 × 10−4, 2.7 × 10−5 3.2 × 10−8, 1.0 × 10−7 7.5 × 10−9, 1.5 × 10−9
1592 1.8 × 10−5, 2.6 × 10−5 3.0 × 10−4, 2.4 × 10−5 9.9 × 10−8, 4.5 × 10−8 9.4 × 10−8, 1.5 × 10−9
1596 3.9 × 10−5, 2.8 × 10−5 1.4 × 10−5, 3.9 × 10−6 1.7 × 10−7, 2.0 × 10−7 3.7 × 10−8, 3.2 × 10−7
2113 1.3 × 10−5, 4.1 × 10−5 6.7 × 10−8, 6.3 × 10−8 1.5 × 10−8, 1.0 × 10−7 4.4 × 10−8, 3.3 × 10−7

*Determined in duplicate.

Main Article

Page created: March 15, 2012
Page updated: March 15, 2012
Page reviewed: March 15, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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