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Volume 18, Number 4—April 2012

Dispatch

De Novo Daptomycin-Nonsusceptible Enterococcal Infections

Theodoros KelesidisComments to Author , Romney Humphries, Daniel Z. Uslan, and David Pegues
Author affiliations: David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Main Article

Table 2

Antimicrobial susceptibilities of DNSE isolates from 9 patients to antimicrobial drugs with activity against Enterococcus spp., Los Angeles, California, USA, 2007–2011*

Patient no. Enterococcus species MIC, μg/mL
Synergy test
DAP† VAN AMP DOX NIT LZD Q-D TGC CIP GEN STR
1 E. faecium ND >32 (R) >64 (R) <1 (S) 128 (R) 2 (S) <0.5 (S) <0.25 (S) >4 (R) S S
2 E. faecium ND >32 (R) >64 (R) 8 (I) 64 (I) 2 (S) <0.5 (S) <0.25 (S) >4 (R) R S
3 E. faecium ND 2 (S) >64 (R) 16 (R) 32 (S) 1 (S) <0.5 (S) <0.25 (S) >4 (R) R R
4 E. faecalis 4 1 (S) <2 (S) 16 (R) <16 (S) 2 (S) 4 (R) <0.25 (S) 1 (S) S S
5 E. faecalis 12 2 (S) <2 (S) 8 (I) <16 (S) 2 (S) 4 (R) <0.25 (S) 1 (S) S S
6 E. faecium 8 >32 (R) >64 (R) 8 (I) 32 (S) 1 (S) 1(S) <0.25 (S) >4 (R) S S
7 E. gallinarum 4 <0.5 (S) <2 (S) <1(S) 32 (S) 1 (S) 1(S) <0.25 (S) <0.5 (S) S S
8 E. faecium 8 >32 (R) >64 (R) 4 (S) 64 (I) 2 (S) <0.5 (S) <0.25 (S) >4 (R) R S
9 E. faecium ND >32 (R) >64 (R) 4 (S) 64 (I) 1 (S) 1 (S) <0.25 (S) >4 (R) R S

*DNSE, daptomycin-nonsusceptible enterococci; DAP, daptomycin; VAN, vancomycin; AMP, ampicillin; DOX, doxycycline; NIT, nitrofurantoin; LZD, linezolid; Q-D, quinupristin/dalfopristin; TGC, tigecycline; CIP, ciprofloxacin; GEN, gentamicin; STR, streptomycin; NS, nonsusceptible; ND, not done; R, resistant; S, sensitive.
†By Etest.

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