Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 18, Number 4—April 2012
Dispatch

De Novo Daptomycin-Nonsusceptible Enterococcal Infections

Theodoros KelesidisComments to Author , Romney Humphries, Daniel Z. Uslan, and David Pegues
Author affiliations: David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Main Article

Table 2

Antimicrobial susceptibilities of DNSE isolates from 9 patients to antimicrobial drugs with activity against Enterococcus spp., Los Angeles, California, USA, 2007–2011*

Patient no. Enterococcus species MIC, μg/mL
Synergy test
DAP† VAN AMP DOX NIT LZD Q-D TGC CIP GEN STR
1 E. faecium ND >32 (R) >64 (R) <1 (S) 128 (R) 2 (S) <0.5 (S) <0.25 (S) >4 (R) S S
2 E. faecium ND >32 (R) >64 (R) 8 (I) 64 (I) 2 (S) <0.5 (S) <0.25 (S) >4 (R) R S
3 E. faecium ND 2 (S) >64 (R) 16 (R) 32 (S) 1 (S) <0.5 (S) <0.25 (S) >4 (R) R R
4 E. faecalis 4 1 (S) <2 (S) 16 (R) <16 (S) 2 (S) 4 (R) <0.25 (S) 1 (S) S S
5 E. faecalis 12 2 (S) <2 (S) 8 (I) <16 (S) 2 (S) 4 (R) <0.25 (S) 1 (S) S S
6 E. faecium 8 >32 (R) >64 (R) 8 (I) 32 (S) 1 (S) 1(S) <0.25 (S) >4 (R) S S
7 E. gallinarum 4 <0.5 (S) <2 (S) <1(S) 32 (S) 1 (S) 1(S) <0.25 (S) <0.5 (S) S S
8 E. faecium 8 >32 (R) >64 (R) 4 (S) 64 (I) 2 (S) <0.5 (S) <0.25 (S) >4 (R) R S
9 E. faecium ND >32 (R) >64 (R) 4 (S) 64 (I) 1 (S) 1 (S) <0.25 (S) >4 (R) R S

*DNSE, daptomycin-nonsusceptible enterococci; DAP, daptomycin; VAN, vancomycin; AMP, ampicillin; DOX, doxycycline; NIT, nitrofurantoin; LZD, linezolid; Q-D, quinupristin/dalfopristin; TGC, tigecycline; CIP, ciprofloxacin; GEN, gentamicin; STR, streptomycin; NS, nonsusceptible; ND, not done; R, resistant; S, sensitive.
†By Etest.

Main Article

Page created: March 14, 2012
Page updated: March 14, 2012
Page reviewed: March 14, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external