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Volume 18, Number 5—May 2012

Research

Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010

Randi Føns PetersenComments to Author , Tine Dalby, Ditte Marie Dragsted, Frits Mooi, and Lotte Lambertsen
Author affiliations: Statens Serum Institut, Copenhagen, Denmark (R.F. Petersen, T. Dalby, L. Lambertsen); private practitioner, Frederiksberg, Denmark (D.M. Dragsted); National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands (F. Mooi)

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Table 2

MLVA typing results for isolates analyzed in a study of temporal trends in Bordetella pertussis populations, Denmark, 1949–2009*

MT No. isolates detected (% frequency)
Total period, n = 260 isolates, 40 MTs Period 1, n = 24 isolates, 8 MTs Period 2, n = 51 isolates, 17 MTs Period 3, n = 185 isolates, 23 MTs
Major MTs
27 122 (47) ND 3 (6) 119 (65)
29 49 (20) 3 (12) 27 (53) 19 (10)
36 8 (3) ND ND 8 (4)
253† 7 (3) 7 (29) ND ND
34 6 (2) ND 2 (4) 4 (2)
141 5 (2) 4 (17) 1 (2) ND
18 4 (1) ND ND 4 (2)
256† 4 (1) 4 (17) ND ND
16 4 (1) ND 1 (2) 3 (2)
Minor MTs‡ 51 (20) 6 (25) 17 (33) 28 (15)

*Genetic diversity was calculated as Simpson index of diversity for each period. The genetic diversity index was calculated for MLVA types by using the online tool Comparing Partitions (www.comparingpartitions.info). Simpson index of diversity (95% CI) was 0.74 (0.69–0.79) for the total period, 0.84 (0.75–0.92) for period 1, 0.71 (0.57–0.85) for period 2, and 0.57 (0.48–0.65) for period 3. MLVA, multilocus variable-number tandem repeat analysis; MT, MLVA type; ND, none detected.
†MTs found in 1–3 isolates.
‡New MTs detected in this study.

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