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Volume 18, Number 5—May 2012

Research

Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010

Randi Føns PetersenComments to Author , Tine Dalby, Ditte Marie Dragsted, Frits Mooi, and Lotte Lambertsen
Author affiliations: Statens Serum Institut, Copenhagen, Denmark (R.F. Petersen, T. Dalby, L. Lambertsen); private practitioner, Frederiksberg, Denmark (D.M. Dragsted); National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands (F. Mooi)

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Table 3

Results of partial sequencing of isolates analyzed in a study of temporal trends in Bordetella pertussis populations, Denmark, 1949–2009*

Partially sequenced gene, alleles detected† No. isolates (% frequency)
Total period Period 1 Period 2 Period 3
prn 153 (100) 24 (100) 50 (100) 79 (100)
prn1 41 (27) 15 (63) 22 (44) 4 (5)
prn2 86 (56) ND 18 (36) 68 (86)
prn3 17 (11) ND 10 (20) 7 (9)
prn7 9 (6) 9 (38) ND ND
ptxA 151 (100) 23 (100) 47 (100) 80 (100)
ptxA1 125 (83) 3 (13) 42 (89) 80 (100)
ptxA2 14 (9) 8 (35) 5 (11) ND
ptxA4 12 (8) 12 (52) ND ND
ptxP 148 (100) 24 (100) 44 (100) 80 (100)
ptxP1 82 (55) 12 (50) 42 (96) 28 (35)
ptxP2 12 (8) 12 (50) ND ND
ptxP3 52 (35) ND 2 (4) 50 (63)
ptxP15 1 (1) ND ND 1 (1)
ptxP17 1 (1) ND ND 1 (1)
tcfA 153 (100) 24 (100) 51 (100) 78 (100)
tcfA2 141 (92) 24 (100) 45 (88) 72 (92)
tcfA3 12 (8) 0 6 (12) 6 (8)

*ND, none detected.
†Genes encoding pertactin (prn), B. pertussis toxin S1 subunit (ptxA), B. pertussis toxin promoter (ptxP), and tracheal colonization factor A (tcfA).

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