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Volume 18, Number 5—May 2012

CME ACTIVITY - Research

Risk Factors for Intestinal Invasive Amebiasis in Japan, 2003–2009

Naoyoshi NagataComments to Author , Takuro Shimbo, Junichi Akiyama, Ryo Nakashima, So Nishimura, Tomoyuki Yada, Koji Watanabe, Shinichi Oka, and Naomi Uemura
Author affiliations: National Center for Global Health and Medicine, Tokyo, Japan (N. Nagata, T. Shimbo, J. Akiyama, R. Nakashima, K. Watanabe, S. Oka); Kohnodai Hospital, Chiba, Japan (S. Nishimura, T. Yada, N. Uemura)

Main Article

Table 2

Risk factors for amebic colitis among HIV-positive and -negative patients, Japan, 2003–2009*

Risk factor HIV-positive patients

HIV-negative patients
p value for interaction
Amebic colitis, n = 31 No amebic colitis, n = 217 OR (95% CI) p value Amebic colitis, n = 23 No amebic colitis, n = 10,659 OR (95% CI) p value
Age, y
>50 6 83 Referent 9 8,777 Referent
<50 25 134 2.6 (1.0–8.0) 0.04 14 1,882 7.3 (2.9–19.0) <0.01 0.11
Sex
F 0 21 Referent 2 4499 Referent
M 31 196 4.6† (0.8–∞) 0.11† 21 6,160 7.7 (1.9–67.5) <0.01 0.56
HBV infection
Negative 26 189 Referent 21 10,510 Referent
Positive 5 28 1.3 (0.4–3.8) 0.62 2 149 6.7 (0.8–27.9) <0.01 0.07
Syphilis
Negative 16 163 Referent 21 10,464 Referent
Positive 15 54 2.8 (1.2–6.5) <0.01 2 195 5.1 (0.6–21.1) 0.01 0.48
Sexual preference
Heterosexual 3 73 Referent ND ND ND ND ND
MSM 28 144 4.7 (1.4–25.0) <0.01 ND ND ND ND ND
CD4 cell count/μL
>300 14 82 Referent ND ND ND ND ND ND
201–300 5 31 0.9 (0.3–2.8) ND ND ND ND ND ND
100–200 9 39 1.35 (0.5–3.4) ND ND ND ND ND ND
<100 3 65 0.3 (0.07–1.0) 0.15 ND ND ND ND ND

*OR, odds ratio; HBV, hepatitis B virus; ND, no applicable data; MSM, men who have sex with men.
†Analysis by using exact logistic regression model because number in cell was 0.

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