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Volume 18, Number 5—May 2012

Dispatch

Use of Spatial Information to Predict Multidrug Resistance in Tuberculosis Patients, Peru

Hsien-Ho Lin, Sonya S. Shin, Carmen Contreras, Luis Asencios, Christopher J. Paciorek, and Ted CohenComments to Author 
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (H.H. Lin, S.S. Shin, T. Cohen); Mennonite Christian Hospital, Hualien, Taiwan (H.H. Lin); National Taiwan University, Taipei, Taiwan (H.H. Lin); Partners In Health, Boston (S.S. Shin); Socios En Salud Sucursal Peru, Lima, Peru (C. Contreras); Instituto Nacional de Salud, Lima (L. Asencios); Harvard School of Public Health, Boston (C.J. Paciorek, T. Cohen); University of California, Berkeley, California, USA (C.J. Paciorek)

Main Article

Table

Risk for MDR TB among TB patients who received DST, by demographic and clinical characteristics, Lima Ciudad and Lima Este, Peru, 2005–2007 *

Characteristic Univariate OR† (95% CI) p value Multivariate OR† (95% CI)‡ p value
Age, per 10-y increase 0.89 (0.81–0.99) 0.034 0.90 (0.81–1.00) 0.046
Male sex 1.09 (0.81–1.46) 0.58 1.05 (0.78–1.43) 0.74
Negative sputum smear test results 2.05 (1.37–3.08) <0.001 2.11 (1.40–3.19) <0.001
HIV infection 0.59 (0.31–1.13) 0.11 0.52 (0.27–1.00) 0.049
History of TB treatment 2.38 (1.78–3.18) <0.001 2.41 (1.80–3.23) <0.001
Known household contact with persons with MDR TB 1.18 (0.89–1.57) 0.25 1.08 (0.81–1.44) 0.59

*MDR, multidrug resistant; TB, tuberculosis; DST, drug-susceptibility testing; OR, odds ratio.
†ORs represent risk for MDR TB conditional on receiving DST. For example, even if household contact with persons with MDR TB is marginally associated with increased risk for MDR TB, the observed association would likely be attenuated when the analysis is restricted to those who received DST because household contact with persons with MDR TB is an accepted criterion for ordering DST.
‡Adjusted for all other variables listed.

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