Fatal Human Co-infection with Leptospira spp. and Dengue Virus, Puerto Rico, 2010
Tyler M. Sharp, Julio Bracero, Aidsa Rivera, Wun-Ju Shieh, Julu Bhatnagar, Irma Rivera-Diez, Elizabeth Hunsperger, Jorge Munoz-Jordan, Sherif R. Zaki, and Kay M. Tomashek
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (T.M. Sharp, W.-J. Shieh, J. Bhatnagar, S.R. Zaki); Centers For Disease Control and Prevention, San Juan, Puerto Rico (T.M. Sharp, A. Rivera, E. Hunsperger, J. Munoz-Jordan, K.M. Tomashek); Hospital Episcopal San Lucas, Ponce, Puerto Rico (J. Barcero); Instituto de Ciencias Forenses Departamento de Patología, San Juan (I. Rivera-Diez)
Figure. . . Histopathologic evaluation of tissue samples collected postmortem from a person co-infected with Leptospira spp. and dengue virus 1. Tissue specimens were taken from the liver (A), lung (B) and kidney (C and D) and stained with hemotoxylin-eosin (A, B, C; original magnification ×20) or probed with poly clonal anti-Leptospira antibody for immunohistochemical detection of Leptospira antigen (D; arrowheads indicate antigen; original magnification ×63).
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