TY - JOUR AU - Mahmud, Salaheddin AU - Van Caeseele, Paul AU - Hammond, Gregory AU - Kurbis, Carol AU - Hilderman, Tim AU - Elliott, Lawrence T1 - No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009 T2 - Emerging Infectious Disease journal PY - 2012 VL - 18 IS - 5 SP - 801 SN - 1080-6059 AB - We conducted a population-based study in Manitoba, Canada, to investigate whether use of inactivated trivalent influenza vaccine (TIV) during the 2008–09 influenza season was associated with subsequent infection with influenza A(H1N1)pdm09 virus during the first wave of the 2009 pandemic. Data were obtained from a provincewide population-based immunization registry and laboratory-based influenza surveillance system. The test-negative case–control study included 831 case-patients with confirmed influenza A(H1N1)pdm09 virus infection and 2,479 controls, participants with test results negative for influenza A and B viruses. For the association of TIV receipt with influenza A(H1N1)pdm09 virus infection, the fully adjusted odds ratio was 1.0 (95% CI 0.7–1.4). Among case-patients, receipt of 2008–09 TIV was associated with a statistically nonsignificant 49% reduction in risk for hospitalization. In agreement with study findings outside Canada, our study in Manitoba indicates that the 2008–09 TIV neither increased nor decreased the risk for infection with influenza A(H1N1)pdm09 virus. KW - epidemiology KW - pandemic influenza A (H1N1), trivalent influenza vaccines, case-control study, influenza, Canada KW - pandemic (H1N1) 2009 KW - pandemic (H1N1) 2009 virus KW - pandemic A(H1N1)2009 virus KW - pandemic influenza A (H1N1) 2009 KW - A(H1N1)pdm09 KW - trivalent influenza vaccine KW - 2008–09 inactivated trivalent influenza vaccine KW - TIV KW - case-control study KW - influenza KW - Canada KW - viruses KW - influenza A(H1N1)pdm09 KW - case–control study DO - 10.3201/eid1805.111596 UR - https://wwwnc.cdc.gov/eid/article/18/5/11-1596_article ER - End of Reference