Figure. . . Phylogenetic tree of human enterovirus C and viral protein (VP) 1 sequences constructed by using the neighbor-joining method. Complete VP1 gene sequences in enterovirus (EV) 104 (888 nt, corresponding to nt 2461–3348 of novel strain AK11) and other human enterovirus C viruses were aligned by using ClustalX version 2 (www.clustal.org). Sequences in EV-95, EV-105, EV-113, and EV-116 were not available from the database. Genetic distances between sequences were calculated by using the Kimura 2-parameter method. Bootstrap values >950 from 1,000 replicates are shown at the nodes. GenBank accession numbers for strains used in this analysis are shown in parentheses. Scale bar indicates nucleotide substitutions per site. CV-A, coxsackievirus A; PV, poliovirus. EV-71 was used as outgroup.
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