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Volume 18, Number 7—July 2012

Dispatch

Seroconversion to Seasonal Influenza Viruses after A(H1N1)pdm09 Virus Infection, Quebec, Canada

Mariana Baz, Jesse Papenburg, Marie-Eve Hamelin, Manale Ouakki, Danuta M. Skowronski, Gaston De Serres, and Guy BoivinComments to Author 
Author affiliations: Author affiliations: Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada (M. Baz, J. Papenburg, M.-E. Hamelin, G. Boivin); Laval University, Quebec City (M. Baz, J. Papenburg, M.-E. Hamelin, G. Boivin); Institut National de Santé Publique du Quebec, Quebec (M. Ouakki, G. De Serres); British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada (D.M. Skowronski)

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Table

Clinical features and microneutralization antibody titers against influenza A(H1N1)pdm09 and seasonal influenza A viruses of persons who seroconverted to >2 influenza viruses, Quebec City, Quebec, Canada, 2009*

Participant no./age, y RT-PCR for A(H1N1) pdm09 Titers, acute phase/convalescent phase (-fold increase)
Symptoms
A/Quebec/147023/ 2009; A(H1N1)pdm09 A/Brisbane/59/ 2007 (H1N1) A/New Caledonia/ 99 (H1N1) A/Panama/2007/99 (H3N2)
ARI ILI
39A/7 + + + <10/160 (16) <10/320 (32) <10/160 (16) 320/160 (0)
39C/11 + + + <10/40 (4) 10/160 (16) <10/40 (4) 2,560/2,560 (0)
49A/28 + + + <10/160 (16) 40/160 (4) <10/20 (2) 320/320 (0)
49B/23 + + + <10/640 (64) <10/160 (16) 40/160 (4) 40/40 (0)
55F/7 + + + <10/40 (4) 10/40 (4) 20/80 (4) 10/10 (0)
16C/7 + + + <10/80 (8) 160/320 (2) 40/160 (4) 80/80 (0)
56A/12 + + + <10/40 (4) 80/320 (4) 40/80 (2) 2,560/2,560 (0)
65B/40 + + + <10/320 (32) <10/20 (2) 10/40 (4) 320/320 (0)
03E/17 + + + <10/80 (8) 40/80 (2) 160/160 (0) 640/5120 (8)
10B/14 + + + <10/80 (8) 20/20 (0) 80/320 (4) 640/640 (0)
11C/61† + + + <10/1,280 (128) 40/160 (4) 160/160 (0) 320/1,280 (4)
44B/9 + + + <10/<80 (8) 1,280/640 (0) 1,280/1,280 (0) 160/640 (4)
44C/44 + <10/20 (2) 10/80 (8) 80/80 (0) 160/640 (4)
58A/13 + + + <10/80 (8) <10/20 (2) 10/20 (2) 1,280/5,120 (4)
58B/43 + + <10/160 (16) <10/10 (0) <10/<10 (0) 20/160 (8)

*RT-PCR, reverse transcription PCR; ARI, acute respiratory illness (i.e., presence of ≥2 of the following signs/symptoms: fever [≥37.8°C] or feverishness, cough, sore throat, or rhinorrhea); ILI, influenza-like illness (i.e., fever and cough and/or sore throat); +, positive; –, negative.
†Received seasonal vaccine in 2008–09.

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