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Volume 18, Number 7—July 2012

Dispatch

Dobrava Hantavirus Infection Complicated by Panhypopituitarism, Istanbul, Turkey, 2010

Nevin Sarıgüzel1Comments to Author , Jörg Hofmann1, Alper Tunga Canpolat, Ali Türk, Jakob Ettinger, Deniz Atmaca, Işın Akyar, Serap Yücel, Ender Arıkan, Yavuz Uyar, Dilek Y. Çağlayık, Ayşe Sesin Kocagöz, Ayşin Kaya, and Detlev H. Kruger
Author affiliations: Acıbadem Hospital, Istanbul, Turkey (N. Sarıgüzel, A.T. Canpolat, D. Atmaca, Serap Yücel, Ender Arıkan); Charité University Medicine, Berlin, Germany (J. Hofmann, J. Ettinger, D.H. Kruger); Labor Berlin Charité-Vivantes GmbH, Berlin (J. Hofmann, J. Ettinger, D. H. Kruger); Acıbadem University, Istanbul (A.Türk, I. Akyar, A. S. Kocagöz); Refik Saydam National Public Health Agency, Ankara, Turkey (Y. Uyar, D. Y. Çağlayık); and University of Geneva, Geneva, Switzerland (A. Kaya)

Main Article

Table 1

Hematologic and biochemical parameters of DOBV hantavirus patient, Istanbul, Turkey, 2010*

Laboratory test (reference range) Day of hospitalization
0 1 2 3 4 5 15 20 71
Leukocytes, × 103 cells/mm3 (4.5–11) 5.8 9.9 15.2 27.6 24 25 11.3 4.7 7.7
Hemoglobin, g/dL (11.7–15.5) 16 16.5 18 16 13.3 10.7 8.2 8.9 12.1
Hematocrit, % (36–46) 46.7 48 51.8 45.2 38.3 31.2 24.6 27 36.6
Platelets, × 103/mm3 (130–450) 63 19 20 13 37 55 180 171 254
ALT, U/L (10–40) 95 92 58 67 157 539 79 60 20
AST, U/L (15–40) 99 117 –† 497 2234 106 84 25
BUN, mg/dL (4.67–23.3) 18 23 30 41 41 129 74 19
Creatinine, mg/dL (0.7–1.2) 0.8 1.8 2.4 3.3 3.1 7.3 6.4 1.92
aPTT, s (4–40) 39 43 32.5 37.1 30.8
PT, s (10–14 s) 13.3 11.6 17.5 20 14.1
Ferritin, ng/mL (15–200) 5,304 14,036
TSH, U/mL (0.4–4.2) 1.71 2.83 0.92
Free thyroxin, pmol/L (10.3–23.2) 0.18 14.3
Cortisol, μg/dL (6.2–19.4) 45.0 0.98 4.7
ACTH, pg/mL (0–46) 3.02 6.80
ADH, pg/mL (0.8–4.5) 2.2
Total testosterone, ng/mL (2.8–8.0) <0.025 1.9
LH, mIU/mL (1.7–8.6) <0.1
FSH, mIU/mL (1.5–12.4) 0.66
Prolactin, mIU/mL (4.6–21.4) 10.05
Somatomedin-C/IGF-1, ng/mL (115–307) <25

*DOBV, Dobrava-Belgrade virus; ALT, alanine transaminase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; aPTT, activated partial thromboplastin time; PT, prothrombin time; TSH, thyroid stimulating hormone; ACTH, adrenocorticotropic hormone; ADH, antidiuretic hormone; LH, luteinizing hormone; FSH, follicle-stimulating hormone; IGF, insulin-like growth factor.
†Test not performed.

Main Article

1These authors contributed equally to this article.

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