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Volume 18, Number 7—July 2012

Research

Spike Protein Fusion Peptide and Feline Coronavirus Virulence

Hui-Wen Chang, Herman F. Egberink, Rebecca Halpin, David J. Spiro, and Peter J.M. RottierComments to Author 
Author affiliations: Utrecht University, Utrecht, the Netherlands (H.-W. Chang, H.F. Egberink, P.J.M. Rottier); and J. Craig Venter Institute, Rockville, Maryland, USA (R. Halpin, D.J. Spiro)

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Figure 2

Alignment of partial nucleotide sequences and translated amino acid sequences in the spike protein of 11 strains each of 2 feline coronavirus pathotypes: FIPVs (lethal) and FECVs (nonvirulent). The viruses were sequenced in a study to distinguish virulent from nonvirulent feline coronaviruses (see Table 1). FIPV strain C1Je (GenBank accession no. DQ848678) was used as the reference for numbering. Sequence positions are shown along the top; virus strains are shown on the right. Specific differenc

Figure 2. . . Alignment of partial nucleotide sequences and translated amino acid sequences in the spike protein of 11 strains each of 2 feline coronavirus pathotypes: FIPVs (lethal) and FECVs (nonvirulent). The viruses were sequenced in a study to distinguish virulent from nonvirulent feline coronaviruses (see Table 1). FIPV strain C1Je (GenBank accession no. DQ848678) was used as the reference for numbering. Sequence positions are shown along the top; virus strains are shown on the right. Specific differences between the pathotypes are boxed. FIPVs, feline infectious peritonitis viruses; FECVs, feline enteric coronaviruses.

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