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Volume 18, Number 8—August 2012

Dispatch

Klebsiella pneumoniae in Gastrointestinal Tract and Pyogenic Liver Abscess

Chang-Phone FungComments to Author , Yi-Tsung Lin, Jung-Chung Lin, Te-Li Chen, Kuo-Ming Yeh, Feng-Yee Chang, Han-Chuan Chuang, Hau-Shin Wu, Chih-Peng Tseng, and L. Kristopher Siu
Author affiliations: Taipei Veterans General Hospital, Taipei, Taiwan (C.P. Fung, Y.T. Lin, T.L. Chen, H.C. Chuang, H.S. Wu, C.P. Tseng); National Yang-Ming University, Taipei (C.P. Fung, Y.T. Lin, T.L. Chen, H.C. Chuang, H.S. Wu, C.P. Tseng); National Defense Medical Center, Taipei (J.C. Lin, K.M. Yeh, F. Y. Chang); National Health Research Institutes, Zhunan, Taiwan (L.K. Siu); and China Medical University, Taichung, Taiwan (L.K. Siu)

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Table 2

Virulence of serotype K1 Klebsiella pneumoniae isolates and clonal relationship from patients with liver abscess and healthy carriers, January 2009–December 2010, Taiwan*

Group no.† Source Serum resistance Phagocytosis, %‡ Mice LD50, CFU
1 P1 R 30.9 <2.6 × 102
HC-1 R 31.0 2.3 × 103
2 P2 R 24.2 <2.9 × 102
P8 R 18.3 <1.5 × 102
HC-2 R 8.8 3.5 × 102
3 P7 S 86.9 >1.7 × 105
P6 R 29.7 2.2 × 102
HC-3 R 35.6 3.0 × 102
4 P13 R 37.6 3.5 × 102
P10 R 30.7 <3.8 × 102
HC-4 R 18.8 <3.0 × 102
5 P11 R 20.4 2.3 × 103
HC-5 R 13.5 <2.4 × 102
6 P9 R 17.8 3.4 × 103
HC-6 R 31.7 1.7 × 103
7 P4 S 35.6 1.9 × 104
HC-7 S 33.1 5.2 × 103

*All groups were positive for the rmpA and aerobactin genes. LD50, 50% lethal dose; P, patient; R, resistant: HC, health carrier; S, sensitive.
†Isolates with an identical or clonally related pulsed-field gel electrophoresis profile from liver aspirate and feces of healthy carriers.
‡Percentage of K. pneumoniae phagocytosed by neutrophils after 15 min.

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