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Volume 18, Number 8—August 2012

Research

Population Diversity among Bordetella pertussis Isolates, United States, 1935–2009

Amber J. Schmidtke, Kathryn O. Boney, Stacey W. Martin, Tami H. Skoff, M. Lucia Tondella, and Kathleen M. TattiComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

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Table

Diversity trends among selected Bordetella pertussis isolates, United States, 1935–2009*

Study period Years Vaccine use Simpson diversity index, % (95% CI)
1 1935–1945 Pre-wP 66.7 (30.4–103.0)
2 1946–1969 Early-wP 77.8 (59.4–96.2)
3 1970–1990 Late-wP 94.0 (90.9–97.1)
4 1991–1996 wP/aP transition (4th–5th doses) 75.7 (65.9–85.5)
5 1997–1999 Early-aP 66.8 (59.5–74.1)
6 2000–2002 Mid-aP 70.2 (67.7–81.1)
7 2003–2005 Late-aP 71.6 (62.4–80.8)
8 2006–2009 Tdap 69.3 (60.7–77.9)

*wP, whole cell vaccine; aP, acellular vaccine; Tdap, tetanus-diphtheria-aP.

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