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Volume 18, Number 8—August 2012

Online Report

Peer Reviewed Report Available Online Only

Infectious Disease Transmission during Organ and Tissue Transplantation

Melissa A. GreenwaldComments to Author , Matthew J. Kuehnert, and Jay A. Fishman
Author affiliations: Food and Drug Administration, Rockville, Maryland, USA (M.A. Greenwald); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.J. Kuehnert); Massachusetts General Hospital, Boston, Massachusetts, USA (J.A. Fishman); and Harvard Medical School, Boston (J.A. Fishman)

Main Article

Table 3

Key research factors and needs for organ and tissue transplant–associated infections

Factor Need
Denominator data Tissue transplantation: number and type of allografts transplanted
Discard rate: number of donors rejected for organ and tissue transplantation because of identified donor risk
Transmissibility data Preclinical: animal studies, studies of unused organs, or tissues from infected donors
Clinical studies: outcomes from increased risk organ donors
Risk mitigation strategies Processing: tissue processing, pump perfusion of organs
Effects of antimicrobial agents: in organ donors, in organ or tissue recipients
Donor questionnaire Effectiveness of questions for obtaining accurate answers and for identifying donors with higher likelihood of having a positive test result
Research infrastructure Organized network: to collect, share, and analyze data in organ and tissue transplantation
Harmonization: product names, label information, data collection methods, data sharing mechanisms
Risk assessment Use of data: model risks, further refine research needs
Quality improvement: evaluate effectiveness of changes, refine models for use with emerging diseases

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