Volume 18, Number 8—August 2012
Online Report
Materials Available Online Only
Infectious Disease Transmission during Organ and Tissue Transplantation
Melissa A. Greenwald
, Matthew J. Kuehnert, and Jay A. Fishman
, Matthew J. Kuehnert, and Jay A. FishmanTable 3
Key research factors and needs for organ and tissue transplant–associated infections
| Factor | Need |
|---|---|
| Denominator data | Tissue transplantation: number and type of allografts transplanted |
| Discard rate: number of donors rejected for organ and tissue transplantation because of identified donor risk | |
| Transmissibility data | Preclinical: animal studies, studies of unused organs, or tissues from infected donors |
| Clinical studies: outcomes from increased risk organ donors | |
| Risk mitigation strategies | Processing: tissue processing, pump perfusion of organs |
| Effects of antimicrobial agents: in organ donors, in organ or tissue recipients | |
| Donor questionnaire | Effectiveness of questions for obtaining accurate answers and for identifying donors with higher likelihood of having a positive test result |
| Research infrastructure | Organized network: to collect, share, and analyze data in organ and tissue transplantation |
| Harmonization: product names, label information, data collection methods, data sharing mechanisms | |
| Risk assessment | Use of data: model risks, further refine research needs |
| Quality improvement: evaluate effectiveness of changes, refine models for use with emerging diseases |
