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Volume 19, Number 1—January 2013

Dispatch

Seropositivity for Influenza A(H1N1)pdm09 Virus among Frontline Health Care Personnel

Kumar Alagappan, Robert A. SilvermanComments to Author , Kathy Hancock, Mary Frances Ward, Meredith Akerman, Fatimah S. Dawood, Alicia Branch, Sandra De Cicco, Evelene Steward-Clark, Megan McCullough, Karen Tenner, and Jacqueline M. Katz
Author affiliations: North Shore–Long Island Jewish Health System, New Hyde Park, New York, USA (K. Alagappan, R.A. Silverman, M.F. Ward, S. De Cicco, M. McCullough, K. Tenner); Hofstra North Shore–Long Island Jewish School of Medicine, Hempstead, New York, USA (K. Alagappan, R.A. Silverman, M.F. Ward); Albert Einstein College of Medicine, Bronx, New York, USA (K. Alagappan, R.A. Silverman); Feinstein Institute for Medical Research, Manhasset, New York, USA (K. Alagappan, R.A. Silverman, M.F Ward, M. Akerman); and Centers for Disease Control and Prevention, Atlanta, Georgia, USA (K. Hancock, F.S. Dawood, A. Branch, E. Steward-Clark, J.M. Katz)

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Table 2

Univariate and multivariate analysis of risk indicators for seropositivity for influenza A(H1N1)pdm09 virus among 340 study participants*

Characteristic No. (%) seropositive, n= 65 No. (%) seronegative, n = 257 Crude OR (95% CI) Adjusted OR (95% CI)
Sex

M

22 (33.9) 116 (42.2) Referent NA

F

43 (66.2) 159 (57.8) 1.41 (0.80–2.49) NA
Age, y

<30

15 (23.1) 41 (14.9) 2.01 (0.60–6.81) NA

30–40

20 (30.8) 65 (23.6) 1.57 (0.48–5.15) NA

41–50

14 (21.5) 67 (24.4) 1.15 (0.34–3.86) NA

51–60

12 (18.5) 79 (28.7) 0.84 (0.25–2.85) NA

>60

4 (6.2) 22 (8.0) Referent NA
Age, y (dichotomized)

<60

61 (93.9) 253 (92.0) 1.32 (0.44–3.96) NA

>60

4 (6.2) 22 (8.0) Referent NA
Received seasonal influenza vaccine during 2008 or 2009 61 (93.9) 252 (91.6) 1.30 (0.43–3.91) NA
Contact with person with suspected A(H1N1)pdm09 virus infection 13 (20.0) 49 (17.8) 1.17 (0.59–2.31) NA
Children <18 y of age at home 36 (55.4) 104 (37.8) 1.96 (1.13–3.40) 1.96 (1.13–3.40)
Occupation

Non-HCP

24 (36.9) 123 (44.7) Referent NA

HCP

41 (63.1) 152 (55.3) 1.35 (0.77–2.36) NA
ILI† during spring–summer 2009 15 (23.1) 19 (6.9) 3.97 (1.85–8.49) NA
ARI‡ during spring–summer 2009 25 (38.5) 53 (19.3) 2.55 (1.41–4.60) NA

*OR, odds ratio; NA, not applicable; HCP, health care personnel; ILI, influenza-like illness; ARI, acute respiratory illness. ILI and ARI were not included in the adjusted logistic regression model because they did not reflect risk for exposure.
†Fever AND either cough or sore throat.
‡Two or more of the following: fever, cough, runny nose, sore throat.

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