Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 19, Number 1—January 2013

CME ACTIVITY

Pneumocystis jirovecii Genotype Associated with Increased Death Rate of HIV-infected Patients with Pneumonia

Meja Rabodonirina, Laetitia Vaillant, Patrick Taffé, Aimable Nahimana, René-Pierre Gillibert, Philippe Vanhems, and Philippe M. HauserComments to Author 
Author affiliations: Author affiliations: Université Claude-Bernard Hôpital de la Croix-Rousse, Lyon, France (M. Rabodonirina); Service d’Hygiène, Epidémiologie et Prévention, Hôpital Edouard Herriot, Lyon (L. Vaillant, R.-P. Gillibert, P. Vanhems); Institut de Veille Sanitaire, Paris, France (L. Vaillant); Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland (P. Taffé, A. Nahimana, P.M. Hauser); Claude Bernard Lyon 1 University, Lyon (P. Vanhems)

Main Article

Table 1

Pneumocystis jiroveci dihydropteroate synthase genotype distribution according to clinical parameters of 112 cases of pneumonia in 110 HIV-positive patients from 5 university hospitals in Lyon, France*

Wild type, n = 75 M2, n = 17 M3, n = 20
Age at PCP diagnosis, y

1–40

41 10 14 0.62

41–60

31 7 5

61–80


3
0
1

Sex

M

62 14 19 0.38

F


13
3
1

Diagnosis year

1993

6 2 0 0.58

1994

24 3 4

1995

20 5 6

1996


25
7
10

CD4 cell count, median cells/μL†

0–50

42 15 11 0.05

51–100

17 0 4

>100


10
0
2

First-line treatment

SMX/TMP

59 14 15 0.90

Pentamidine or atovaquone

14 3 5

Others


2
0
0

SMX/TMP allergy

Yes

4 0 3 0.27

No


71
17
17

Corticotherapy at PCP diagnosis

Yes

18 1 3 0.25

No


57
16
17

Mechanical ventilation at PCP diagnosis

Yes

11 0 3 0.26

No


64
17
17

P. jirovecii SSCP type 1 3 6 1 <0.001

7

3 0 6

10

2 1 1

Others

30 3 3

Co-infected


37
7
9

Outcome within 1 month

Favorable

61 16 14 0.39

Death attributed to PCP

12 1 5

Death not attributed to PCP

2 0 1

*Data derived from Fisher’s exact test. DHPS, dihydropteroate synthase; M, mutation; SSCP, single-strand conformation polymorphism; PCP, P. jirovecii pneumonia; SMX/TMP, sulfamethoxazole and trimethoprim.
†Data missing for 11 patients.

Main Article

TOP