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Volume 19, Number 1—January 2013

CME ACTIVITY - Research

Pneumocystis jirovecii Genotype Associated with Increased Death Rate of HIV-infected Patients with Pneumonia

Meja Rabodonirina, Laetitia Vaillant, Patrick Taffé, Aimable Nahimana, René-Pierre Gillibert, Philippe Vanhems, and Philippe M. HauserComments to Author 
Author affiliations: Author affiliations: Université Claude-Bernard Hôpital de la Croix-Rousse, Lyon, France (M. Rabodonirina); Service d’Hygiène, Epidémiologie et Prévention, Hôpital Edouard Herriot, Lyon (L. Vaillant, R.-P. Gillibert, P. Vanhems); Institut de Veille Sanitaire, Paris, France (L. Vaillant); Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland (P. Taffé, A. Nahimana, P.M. Hauser); Claude Bernard Lyon 1 University, Lyon (P. Vanhems)

Main Article

Table 2

Pneumocystis jiroveci SSCP genotype distribution according to clinical parameters of 112 cases of pneumonia in 110 HIV-positive patients from 5 university hospitals in Lyon, France*

1, n = 10 7, n = 9 10, n = 4 Others, n = 36 Co-infected, n = 53
Age at PCP diagnosis, y

1–40

8 5 2 22 28 0.89

41–60

2 4 2 13 22

61–80


0
0
0
1
3

Sex

M

3 1 1 6 6 0.44

F


7
8
3
30
47

Diagnosis year

1993

1 0 0 2 5 0.90

1994

3 2 2 8 16

1995

2 2 1 9 17

1996


4
5
1
17
15

CD4 cell count, median cells/μL†

0–50

7 5 3 23 30 0.87

51–100

0 2 1 6 12

>100


1
1
0
5
5

First-line treatment

SMX/TMP

7 3 3 26 49 0.001

Pentamidine or atovaquone

2 6 1 9 4

Others


1
0
0
1
0

SMX/TMP allergy

Yes

0 2 0 3 2 0.27

No


10
7
4
33
51

Corticotherapy at PCP diagnosis

Yes

0 4 0 7 11 0.17

No


10
5
4
29
42

Mechanical ventilation at PCP diagnosis

Yes

0 2 0 2 10 0.19

No


10
7
4
34
43

Outcome within 1 month

Favorable

9 5 4 28 45 0.44

Death attributed to PCP

1 4 0 6 7

Death not attributed to PCP

0 0 0 2 1

*Data derived from Fisher’s exact test. SSCP, single-strand conformation polymorphism; PCP, P. jirovecii pneumonia; SMX/TMP, sulfamethoxazole and trimethoprim.
†Data missing for 11 patients.

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