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Volume 19, Number 1—January 2013

CME ACTIVITY

Pneumocystis jirovecii Genotype Associated with Increased Death Rate of HIV-infected Patients with Pneumonia

Meja Rabodonirina, Laetitia Vaillant, Patrick Taffé, Aimable Nahimana, René-Pierre Gillibert, Philippe Vanhems, and Philippe M. HauserComments to Author 
Author affiliations: Author affiliations: Université Claude-Bernard Hôpital de la Croix-Rousse, Lyon, France (M. Rabodonirina); Service d’Hygiène, Epidémiologie et Prévention, Hôpital Edouard Herriot, Lyon (L. Vaillant, R.-P. Gillibert, P. Vanhems); Institut de Veille Sanitaire, Paris, France (L. Vaillant); Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland (P. Taffé, A. Nahimana, P.M. Hauser); Claude Bernard Lyon 1 University, Lyon (P. Vanhems)

Main Article

Table 3

Multivariate analysis of risk factors for death attributed to PCP among 112 cases in 110 patients from 5 university hospitals, Lyon, France

Risk factor Death attributed to PCP
Adjusted RH (95% CI)† p value
Yes No
P. jirovecii PCR-SSCP type

7

4 5 4.2 (1.0–17.9) 0.05

Others


14
89
1.0 (Reference)

Mechanical ventilation at PCP diagnosis

Yes

8 6 5.0 (1.8–13.5) 0.002

No


10
88
1.0 (Reference)

DHPS genotype

M3

5 15 1.1 (0.4–3.4) 0.82

M2

1 16 0.6 (0.08–5.1) 0.66

Wild type


12
63
1.0 (Reference)

Mean age at PCP diagnosis, y
38.5
40.6
1.0
0.95
First-line treatment

Others

3 19 0.4 (0.1–2.0) 0.29

Sulfonamides

15 75 1.0 (Reference)

*PCP, Pneumocystis jirovecii pneumonia; RH, relative hazard; SSCP, single-strand conformation polymorphism; DHPS, dihydropteroate synthase; M, mutation.
†RH for death attributed to PCP after adjustment for the 5 variables presented in the table. The global p value of the test for proportionality was 0.55, and no individual test was statistically significant at the 0.05 level.

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