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Volume 19, Number 1—January 2013

Dispatch

Klebsiella pneumoniae Antimicrobial Drug Resistance, United States, 1998–2010

Guillermo V. Sanchez, Ronald N. Master, Richard B. Clark, Madiha Fyyaz, Padmaraj Duvvuri, Gupta Ekta, and Jose BordonComments to Author 
Author affiliations: Author affiliations: George Washington University, Washington, DC, USA (G.V. Sanchez); Quest Diagnostics Nichols Institute, Chantilly, Virginia, USA (R.N. Master, R.B. Clark); Providence Hospital, Washington (M. Fyyaz, P. Duvvuri, G. Ekta, J. Bordon)

Main Article

Table 1

Klebsiella pneumoniae antimicrobial drug resistance among inpatients, by year, United States, 1998–2010*

Antimicrobial drug No. 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 Total change†
TET 80,862 14.2 14.7 14.6 13.9 14.2 13 15.6 14.8 15.6 15.2 15.3 16.4 16.7 2.5
AMK 232,933 0.7 0.9 0.8 0.9 1 1.1 2.1 3.7 4.9 4.6 4.9 4.6 4.5 3.8
IPM 259,589 0 0 0 0 0 0 0.3 0.6 0.6 1.5 3.3 3.8 4.3 4.3
GEN 344,597 4.9 4.6 4.6 5.2 5.5 5.6 6.9 8.3 8.4 7.8 8.7 9.1 9.2 4.3
CPM 211,134 2.1 2 2.7 2.3 2.3 2.5 5.1 5.3 5.5 5.8 7.7 7.3 7.7 5.6
TMP/SXT 344,522 10.9 11 10.9 10.4 10.4 10.9 13 15 16.2 16.5 19.4 18.9 19.3 8.4
TZP 250,554 4 5.5 5.4 5.3 5.3 5.6 7.7 8.8 8.4 7.8 10.5 12 12.7 8.7
TOB 289,287 4.6 4.5 4.4 4.8 5.2 5.5 8 9.8 11.9 10.4 13.2 13.2 13.8 9.2
CRO 287,091 1.8 2.7 3.2 2.9 2.6 3.1 5.7 6.9 8.1 8.7 11.1 11.2 12.1 10.3
CIP 306,348 5.5 6.1 6.5 7 7.6 7.9 9.9 11.7 14.4 14.6 17 16.8 16.8 11.3
CAZ 248,004 5.5 6.8 7.9 7.9 7.7 7.8 11.3 13.3 12.3 12.3 15.6 15.2 17.2 11.7
ATM 184,981 7.7 7.7 7.7 7.5 8 7.3 11.2 12.9 12.8 12.8 16.6 16.1 22.2 14.5

*TET, tetracycline; AMK, amikacin; IPM, imipenem; GEN, gentamicin; CPM, cefepime; TMP/SXT, trimethoprim/sulfamethoxazole; TZP, piperacillin/tazobactam; TOB, tobramycin; CRO, ceftriaxone; CIP, ciprofloxacin; CAZ, ceftazidime; ATM, aztreonam.
†Change from 1998 to 2010. p<0.0001 for all antimicrobial agents except tetracycline (p = 0.0745).

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