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Volume 19, Number 1—January 2013

Research

Invasive Pneumococcal Disease after Routine Pneumococcal Conjugate Vaccination in Children, England and Wales

Shamez N. LadhaniComments to Author , Mary P.E. Slack, Nick J. Andrews, Pauline A. Waight, Ray Borrow, and Elizabeth Miller
Author affiliations: Author affiliations: Health Protection Services Colindale, London, UK (S.N. Ladhani, M.P.E. Slack, N.J Andrews, P.A Waight, E. Miller); Health Protection Agency, Manchester, UK (R. Borrow)

Main Article

Table 3

Association between infecting pneumococcal serotype group and presence of comorbidity, England and Wales, September 4, 2006–March 31, 2010*

Serotype group Comorbidity, no./total (%) aOR† (95% CI) p value
All PCV7-IPD cases‡ 44/248 (17.7)
3 extra PCV10 serotypes (1, 5, 7F)
15/299 (5.0) §
0.24 (0.13–0.45) against PCV7
<0.001
3 extra PCV13 serotypes (3, 6A, 19A) 45/336 (13.4)§ 0.72 (0.46–1.13) against PCV7 0.15


3.58 (1.93–6.66) against PCV10‡
<0.001
11 extra PPV23 serotypes 39/186 (21.0) 1.23 (0.76–1.99) against PCV7 0.40
6.02 (3.16–11.5) against PCV10 <0.001


1.68 (1.04–2.71) against PCV13
0.033
Remaining non-PPV23 serotypes 38/138 (27.5) 1.76 (1.07–2.89) against PCV7 0.025
8.57 (4.46–16.5) against PCV10 <0.001
2.39 (1.46–3.93) against PCV13 0.001
1.42 (0.85–2.40) against PPV23 0.18

*aOR, adjusted odds ration; PCV7, 7-valent pneumococcal conjugate vaccine; PCV10, 10-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine; PPV23, 23-valent polysaccharide vaccine.
†Odds ratio adjusted for age, vaccination status, and time since PCV7 introduction by using a multinomial logistic regression with serotype group as the outcome.
‡Serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F.
§Comorbidity was lower for each of the 3 extra PCV10 serotypes, 1 (7/129, 5.4%), 5 (1/17, 5.9%), and 7F (7/153, 4.6%), compared with the additional 3 serotypes in PCV13, 3 (13/98, 13.3%), 6A (12/47, 25.5%), and 19A (20/191, 10.5%).

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