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Volume 19, Number 10—October 2013

CME ACTIVITY - Research

Increased Incidence of Invasive Fusariosis with Cutaneous Portal of Entry, Brazil

Marcio NucciComments to Author , Andrea G. Varon, Marcia Garnica, Tiyomi Akiti, Gloria Barreiros, Beatriz Moritz Trope, and Simone A. Nouér
Author affiliations: University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Main Article

Table

Characteristics of 21 patients with invasive fusariosis in the hematology united at University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, 2000–2010*

Characteristic Patients
Sex, M:F 16:5
Median age, y (range)
55 (9–71)
Underlying disease
Acute myeloid leukemia 9 (42.9)
Multiple myeloma 4 (19.0)
Non-Hodgkin lymphoma 2 (9.5)
Acute lymphoid leukemia 2 (9.5)
Myelodysplasia 2 (9.5)
Aplastic anemia 1 (4.8)
Chronic myeloid leukemia
1 (4.8)
HCT recipients 12 (57.1)
Allogeneic 8 (38.1)
Autologous
4 (19.0)
Room with HEPA filter 14 (66.7)
Receipt of corticosteroids
16 (76.2)
Graft-versus-host disease, n = 8† 6 (75.0)
Neutropenia 17 (81.0)
Skin as portal of entry 17 (81.0)
Positive blood culture
11 (52.4)
Classification of fusariosis
Proven 20 (95.2)
Probable
1 (4.8)
Primary treatment
None 1 (4.8)
Voriconazole 7 (33.3)
Deoxycholate amphotericin B 10 (47.6)
Deoxycholate amphotericin B + voriconazole 3 (14.3)

*Values are no. (%) patients except as indicated. HCT, hematopoietic cell transplant; HEPA, high-efficiency particulate air.
†Allogeneic HCT recipients.

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