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Volume 19, Number 10—October 2013

Research

Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2

Na Li, Lihua Xiao, Vitaliano A. Cama, Ynes Ortega, Robert H. Gilman, Meijin Guo, and Yaoyu FengComments to Author 
Author affiliations: East China University of Science and Technology, Shanghai, China (N. Li, M. Guo, Y. Feng); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (N. Li, L. Xiao, V.A. Cama); University of Georgia, Griffin, Georgia, USA (Y. Ortega); Johns Hopkins University, Baltimore, Maryland, USA (R.H. Gilman)

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Table 2

Intragenic analyses of 53 Cryptosporidium hominis specimens at 25 polymorphic loci in chromosome 6*

No. Locus Position in chromosome 6 Haplotype diversity No. haplotypes Polymorphic sites, bp† Segregating sites, bp‡ Intragenic LD Intragenic recombination events
1 CP56 5451–6129 0.4819 3 2 1 NA NA
2 MSC6–7 12415–12945 0.4819 3 40 1 NA NA
3 C6–60 22017–22807 0.9231 21 98 3 Y = 1.0000 + 0.0000X 0
4 C6–160 44235–44783 0.6727 3 7 0 NA NA
5 C6–230 58658–59234 0.4906 6 79 1 NA NA
6 C6–280 70850–71454 0.5530 3 42 3 Y = 1.0000 + 0.0000X 0
7 C6–350 84688–85277 0.4136 2 21 12 Y = 1.0000 + 0.0000X 0
8 C6–580 138267–138866 0.2409 3 2 2 NA NA
9 C6–740 188916–189541 0.5791 5 7 1 NA NA
10 C6–830′ 210232–210884 0.1742 2 1 1 NA NA
11 C6–1000′ 251594–252087 0.3832 3 35 20 Y = 1.0000 + 0.0000X 0
12 gp60 266540–267350 0.7090 6 431 297 Y = 0.9729 + 0.0130X 26
13 C6–1420 338725–339242 0.2083 3 13 1 NA NA
14 CP47 372535–372907 0.8084 6 113 7 Y = 1.0000 + 0.0000X 0
15 C6–2600 606026–606798 0.3570 2 1 1 NA NA
16 C6–2970 685852–686541 0.3570 2 6 2 NA NA
17 C6–3110′ 721467–722169 0.0377 2 9 0 NA NA
18 C6–3520 820500–821215 0.4136 2 6 0 NA NA
19 C6–3520′ 822524–823076 0.0377 2 1 1 NA NA
20 C6–3690 864809–865416 0.4688 2 1 1 NA NA
21 DZ-HRGP 917600–918139 0.1742 2 3 0 NA NA
22 C6–4110 956461–957083 0.4115 4 27 5 Y = 1.0000 + 0.0000X 0
23 C6–5110′ 1206378–1206774 0.2663 3 8 2 NA NA
24 C6–5120 1213134–1213677 0.2612 2 6 0 NA NA
25 C6–5410 1285377–1286003 0.5218 3 9 0 NA NA

*LD, linkage disequilibrium, where Y is the LD value, and X is the nucleotide distance in kilobases; NA, analysis is not applicable for the locus, which has <3 segregating sites.
†Polymorphic sites including insertions/deletions (indels).
‡Segregating sites excluding indels.

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